Viral polymerases

Research output: Chapter in Book/Report/Conference proceedingChapter

38 Scopus citations

Abstract

Viral polymerases play a central role in viral genome replication and transcription. Based on the genome type and the specific needs of particular virus, RNA-dependent RNA polymerase, RNA-dependent DNA polymerase, DNA-dependent RNA polymerase, and DNA-dependent RNA polymerases are found in various viruses. Viral polymerases are generally active as a single protein capable of carrying out multiple functions related to viral genome synthesis. Specifically, viral polymerases use variety of mechanisms to recognize initial binding sites, ensure processive elongation, terminate replication at the end of the genome, and also coordinate the chemical steps of nucleic acid synthesis with other enzymatic activities. This review focuses on different viral genome replication and transcription strategies, and the polymerase interactions with various viral proteins that are necessary to complete genome synthesis.

Original languageEnglish (US)
Title of host publicationViral Molecular Machines
EditorsMichael Rossmann, Venigalla Rao
Pages267-304
Number of pages38
DOIs
StatePublished - Mar 19 2012

Publication series

NameAdvances in Experimental Medicine and Biology
Volume726
ISSN (Print)0065-2598

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Choi, K. H. (2012). Viral polymerases. In M. Rossmann, & V. Rao (Eds.), Viral Molecular Machines (pp. 267-304). (Advances in Experimental Medicine and Biology; Vol. 726). https://doi.org/10.1007/978-1-4614-0980-9_12