Viral–bacterial interactions within hosts

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Coinfections with pathogens that have opportunistic or synergistic mechanisms of action pose important clinical challenges. Treatment of dual infections can be hampered by dysregulation of the host immune response, synergistic pathogenesis of infectious agents, and compromise of therapeutics by the host response or mixed drug regimens. Understanding the mechanistic basis for coinfection pathogenesis is key to improving existing therapies and informing novel clinical approaches. This chapter summarizes our current understanding of pathophysiological mechanisms for bacterial coinfections that are important causes of morbidity and mortality in patients with influenza or human immunodeficiency virus infection.

Original languageEnglish (US)
Title of host publicationMolecular Medical Microbiology, Third Edition
PublisherElsevier
Pages489-500
Number of pages12
ISBN (Electronic)9780128186190
DOIs
StatePublished - Jan 1 2023
Externally publishedYes

Keywords

  • Coinfection
  • Mycobacterium tuberculosis
  • Staphylococcus aureus
  • Streptococcus pneumoniae
  • human immunodeficiency virus
  • influenza virus
  • pneumonia

ASJC Scopus subject areas

  • General Immunology and Microbiology

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