Virologic investigation of a case of suspected haemorrhagic fever

R. H. Kenyon, Bo Niklasson, P. B. Jahrling, Thomas Geisbert, L. Svensson, A. Frydén, M. Bengtsson, U. Foberg, C. J. Peters

Research output: Contribution to journalArticle

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Abstract

After travelling in subSaharan Africa, an area known for sporadic cases of Marburg virus infection, a young Swedish man presented with a classical picture of severe viral haemorrhagic fever complicated by disseminated intravascular coagulation and septicaemia. Serum samples examined by electron microscopy revealed particles of a size compatible with filovirions. Indirect fluorescent antibody tests indicated transient seroconversion to Marburg virus. In lymphocyte transformation assays of cells isolated from the patient 11 months after the onset of acute disease, Marburg viral antigen was able to stimulate lymphocyte proliferation 3.9-fold; however, exhaustive attempts to isolate virus from acute phase blood cultured in vitro or in vivo from guinea pigs and monkeys failed. Data suggest that this patient may have been infected with a filovirus. This case demonstrates the difficulties that may occur in laboratory diagnosis of viral haemorrhagic fevers.

Original languageEnglish (US)
Pages (from-to)397-406
Number of pages10
JournalResearch in Virology
Volume145
Issue numberC
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Marburgvirus
Viral Hemorrhagic Fevers
Fever
Viral Antigens
Disseminated Intravascular Coagulation
Africa South of the Sahara
Clinical Laboratory Techniques
Acute Disease
Virus Diseases
Lymphocyte Activation
Particle Size
Haplorhini
Sepsis
Electron Microscopy
Guinea Pigs
Lymphocytes
Viruses
Antibodies
Serum

Keywords

  • Filovirion
  • Marburg virus
  • Subsaharan Africa
  • Viral haemorrhagic fever

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Kenyon, R. H., Niklasson, B., Jahrling, P. B., Geisbert, T., Svensson, L., Frydén, A., ... Peters, C. J. (1994). Virologic investigation of a case of suspected haemorrhagic fever. Research in Virology, 145(C), 397-406. https://doi.org/10.1016/S0923-2516(07)80046-X

Virologic investigation of a case of suspected haemorrhagic fever. / Kenyon, R. H.; Niklasson, Bo; Jahrling, P. B.; Geisbert, Thomas; Svensson, L.; Frydén, A.; Bengtsson, M.; Foberg, U.; Peters, C. J.

In: Research in Virology, Vol. 145, No. C, 1994, p. 397-406.

Research output: Contribution to journalArticle

Kenyon, RH, Niklasson, B, Jahrling, PB, Geisbert, T, Svensson, L, Frydén, A, Bengtsson, M, Foberg, U & Peters, CJ 1994, 'Virologic investigation of a case of suspected haemorrhagic fever', Research in Virology, vol. 145, no. C, pp. 397-406. https://doi.org/10.1016/S0923-2516(07)80046-X
Kenyon, R. H. ; Niklasson, Bo ; Jahrling, P. B. ; Geisbert, Thomas ; Svensson, L. ; Frydén, A. ; Bengtsson, M. ; Foberg, U. ; Peters, C. J. / Virologic investigation of a case of suspected haemorrhagic fever. In: Research in Virology. 1994 ; Vol. 145, No. C. pp. 397-406.
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