Virus-induced corticosterone in hypophysectomized mice: A possible lymphoid adrenal axis

Eric M. Smith, Walter Meyer, J. Edwin Blalock

Research output: Contribution to journalArticle

201 Citations (Scopus)

Abstract

Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment with dexamethasone completely inhibited the virus-induced elevation in corticosterone concentration, but did not significantly alter the interferon response. Lymphocytes appear to be the most likely source of an adrenocorticotropin-like substance that is responsible for the increased corticosterone, since spleen cells from the virus-infected, but not from control or dexamethasone-treated, hypophysectomized mice showed positive immunofluorescence with antibody to adrenocorticotropin-(1-13 amide). Thus the adrenocorticotropin-like material and interferon appear to be coordinately induced and differentially controlled products of different genes. These findings strongly suggest the existence of a lymphoid-adrenal axis.

Original languageEnglish (US)
Pages (from-to)1311-1312
Number of pages2
JournalScience
Volume218
Issue number4579
StatePublished - 1982

Fingerprint

Corticosterone
Adrenocorticotropic Hormone
Interferons
Viruses
Dexamethasone
Newcastle disease virus
Amides
Fluorescent Antibody Technique
Spleen
Lymphocytes
Antibodies
Infection
Genes
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

Smith, E. M., Meyer, W., & Edwin Blalock, J. (1982). Virus-induced corticosterone in hypophysectomized mice: A possible lymphoid adrenal axis. Science, 218(4579), 1311-1312.

Virus-induced corticosterone in hypophysectomized mice : A possible lymphoid adrenal axis. / Smith, Eric M.; Meyer, Walter; Edwin Blalock, J.

In: Science, Vol. 218, No. 4579, 1982, p. 1311-1312.

Research output: Contribution to journalArticle

Smith, EM, Meyer, W & Edwin Blalock, J 1982, 'Virus-induced corticosterone in hypophysectomized mice: A possible lymphoid adrenal axis', Science, vol. 218, no. 4579, pp. 1311-1312.
Smith EM, Meyer W, Edwin Blalock J. Virus-induced corticosterone in hypophysectomized mice: A possible lymphoid adrenal axis. Science. 1982;218(4579):1311-1312.
Smith, Eric M. ; Meyer, Walter ; Edwin Blalock, J. / Virus-induced corticosterone in hypophysectomized mice : A possible lymphoid adrenal axis. In: Science. 1982 ; Vol. 218, No. 4579. pp. 1311-1312.
@article{440472b3caa14556abf5285c8b0083b4,
title = "Virus-induced corticosterone in hypophysectomized mice: A possible lymphoid adrenal axis",
abstract = "Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment with dexamethasone completely inhibited the virus-induced elevation in corticosterone concentration, but did not significantly alter the interferon response. Lymphocytes appear to be the most likely source of an adrenocorticotropin-like substance that is responsible for the increased corticosterone, since spleen cells from the virus-infected, but not from control or dexamethasone-treated, hypophysectomized mice showed positive immunofluorescence with antibody to adrenocorticotropin-(1-13 amide). Thus the adrenocorticotropin-like material and interferon appear to be coordinately induced and differentially controlled products of different genes. These findings strongly suggest the existence of a lymphoid-adrenal axis.",
author = "Smith, {Eric M.} and Walter Meyer and {Edwin Blalock}, J.",
year = "1982",
language = "English (US)",
volume = "218",
pages = "1311--1312",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "4579",

}

TY - JOUR

T1 - Virus-induced corticosterone in hypophysectomized mice

T2 - A possible lymphoid adrenal axis

AU - Smith, Eric M.

AU - Meyer, Walter

AU - Edwin Blalock, J.

PY - 1982

Y1 - 1982

N2 - Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment with dexamethasone completely inhibited the virus-induced elevation in corticosterone concentration, but did not significantly alter the interferon response. Lymphocytes appear to be the most likely source of an adrenocorticotropin-like substance that is responsible for the increased corticosterone, since spleen cells from the virus-infected, but not from control or dexamethasone-treated, hypophysectomized mice showed positive immunofluorescence with antibody to adrenocorticotropin-(1-13 amide). Thus the adrenocorticotropin-like material and interferon appear to be coordinately induced and differentially controlled products of different genes. These findings strongly suggest the existence of a lymphoid-adrenal axis.

AB - Infection of hypophysectomized mice with Newcastle disease virus caused a time-dependent increase in corticosterone and interferon production. Prior treatment with dexamethasone completely inhibited the virus-induced elevation in corticosterone concentration, but did not significantly alter the interferon response. Lymphocytes appear to be the most likely source of an adrenocorticotropin-like substance that is responsible for the increased corticosterone, since spleen cells from the virus-infected, but not from control or dexamethasone-treated, hypophysectomized mice showed positive immunofluorescence with antibody to adrenocorticotropin-(1-13 amide). Thus the adrenocorticotropin-like material and interferon appear to be coordinately induced and differentially controlled products of different genes. These findings strongly suggest the existence of a lymphoid-adrenal axis.

UR - http://www.scopus.com/inward/record.url?scp=0020363970&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020363970&partnerID=8YFLogxK

M3 - Article

C2 - 6183748

AN - SCOPUS:0020363970

VL - 218

SP - 1311

EP - 1312

JO - Science

JF - Science

SN - 0036-8075

IS - 4579

ER -