Complex regional pain syndrome (CRPS) is a devastating condition often seen after extremity injury and surgery. Prevention of this pathology is attractive not only to patients but also to healthcare providers, as the management of this condition when it becomes chronic can be difficult. One of the safest and efficacious regimens which can be used to prevent occurrence of CRPS in patients with extremity surgery and trauma is the use of daily, highdose vitamin C for several weeks. A daily dose of more than 500 mg has been recommended by clinical studies, a systematic review with meta-analysis, and a multidisciplinary guideline. Efficacy and safety of vitamin C used to prevent CRPS are discussed.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)