Vitamin c, extremity trauma and surgery

Naohiro Shibuya, Monica R. Agarwal, Daniel C. Jupiter

    Research output: Chapter in Book/Report/Conference proceedingChapter


    Complex regional pain syndrome (CRPS) is a devastating condition often seen after extremity injury and surgery. Prevention of this pathology is attractive not only to patients but also to healthcare providers, as the management of this condition when it becomes chronic can be difficult. One of the safest and efficacious regimens which can be used to prevent occurrence of CRPS in patients with extremity surgery and trauma is the use of daily, highdose vitamin C for several weeks. A daily dose of more than 500 mg has been recommended by clinical studies, a systematic review with meta-analysis, and a multidisciplinary guideline. Efficacy and safety of vitamin C used to prevent CRPS are discussed.

    Original languageEnglish (US)
    Title of host publicationDiet and Nutrition in Critical Care
    PublisherSpringer New York
    Number of pages6
    ISBN (Electronic)9781461478362
    ISBN (Print)9781461478379
    StatePublished - Jan 1 2015

    ASJC Scopus subject areas

    • Medicine(all)
    • Biochemistry, Genetics and Molecular Biology(all)


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