Vitamin c, extremity trauma and surgery

Naohiro Shibuya, Monica R. Agarwal, Daniel Jupiter

Research output: Chapter in Book/Report/Conference proceedingChapter


Complex regional pain syndrome (CRPS) is a devastating condition often seen after extremity injury and surgery. Prevention of this pathology is attractive not only to patients but also to healthcare providers, as the management of this condition when it becomes chronic can be difficult. One of the safest and efficacious regimens which can be used to prevent occurrence of CRPS in patients with extremity surgery and trauma is the use of daily, highdose vitamin C for several weeks. A daily dose of more than 500 mg has been recommended by clinical studies, a systematic review with meta-analysis, and a multidisciplinary guideline. Efficacy and safety of vitamin C used to prevent CRPS are discussed.

Original languageEnglish (US)
Title of host publicationDiet and Nutrition in Critical Care
PublisherSpringer New York
Number of pages6
ISBN (Print)9781461478362, 9781461478379
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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