Vitamin D and endothelial vasodilation in older individuals

Data from the PIVUS study

Marcello Maggio, Francesca De Vita, Fulvio Lauretani, Gian Paolo Ceda, Elena Volpi, Francesco Giallauria, Giuseppe De Cicco, Chiara Cattabiani, Håkan Melhus, Karl Michaëlsson, Tommy Cederholm, Lars Lind

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Context: Vitamin D plays a role in a wide range of extraskeletal processes, including vascular function. Endothelial dysfunction is a predictor of cardiovascular disease, especially in older subjects. However, the relationship between vitamin D levels and indexes of endothelial vasodilation has never been fully addressed in older individuals. Copyright

Objective: The objective of this study was to examine the association between vitamin D and endothelial function in a large community-based sample of older subjects.

Methods: This cross-sectional study involved 852 community-dwelling men and women aged 70 years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), with complete data on vascular function and 25-hydroxyvitamin D. We evaluated endothelium-dependent vasodilation by an invasive forearm technique with acetylcholine, endothelium-independent vasodilation by sodium nitroprussiate, flow-mediated vasodilation, and the pulse wave analysis (reflectance index). Vitamin D levels were measured by chemiluminescence. We used multivariate regression models adjusted for body mass index (model 1) and for multiple confounders (high-sensitivity C-reactive protein, insulin, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein- cholesterol, smoking, sex hormones, season of blood collection, hypertension, diabetes, cardiovascular medications and diseases, statin usage, plasma calcium and calcium intake, PTH, physical exercise, liver and kidney function tests, albumin; model 2).

Results: In women, but not in men, vitamin D levels were positively associated with endotheliumindependent vasodilation in both model 1 (β ± SE = 1.41 ± 0.54; P = .001), and model 2 (β ± SE = 2.01 ± 0.68; P = .003).We found no significant relationship between vitamin D levels and endothelium- dependent vasodilation, flow-mediated vasodilation, and reflectance index in both sexes.

Conclusions: In older women, but not in men, vitamin D is positively and independently associated with EIDV.

Original languageEnglish (US)
Pages (from-to)3382-3389
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume99
Issue number9
DOIs
StatePublished - Sep 1 2014

Fingerprint

Vasodilation
Vitamin D
Prospective Studies
Endothelium
Blood Vessels
Cardiovascular Diseases
Kidney Function Tests
Calcium
Independent Living
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Pulse Wave Analysis
Chemiluminescence
Liver Function Tests
Cholesterol
Gonadal Steroid Hormones
Medical problems
Luminescence
Forearm
Liver
C-Reactive Protein

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Vitamin D and endothelial vasodilation in older individuals : Data from the PIVUS study. / Maggio, Marcello; De Vita, Francesca; Lauretani, Fulvio; Ceda, Gian Paolo; Volpi, Elena; Giallauria, Francesco; De Cicco, Giuseppe; Cattabiani, Chiara; Melhus, Håkan; Michaëlsson, Karl; Cederholm, Tommy; Lind, Lars.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 99, No. 9, 01.09.2014, p. 3382-3389.

Research output: Contribution to journalArticle

Maggio, M, De Vita, F, Lauretani, F, Ceda, GP, Volpi, E, Giallauria, F, De Cicco, G, Cattabiani, C, Melhus, H, Michaëlsson, K, Cederholm, T & Lind, L 2014, 'Vitamin D and endothelial vasodilation in older individuals: Data from the PIVUS study', Journal of Clinical Endocrinology and Metabolism, vol. 99, no. 9, pp. 3382-3389. https://doi.org/10.1210/jc.2014-1536
Maggio, Marcello ; De Vita, Francesca ; Lauretani, Fulvio ; Ceda, Gian Paolo ; Volpi, Elena ; Giallauria, Francesco ; De Cicco, Giuseppe ; Cattabiani, Chiara ; Melhus, Håkan ; Michaëlsson, Karl ; Cederholm, Tommy ; Lind, Lars. / Vitamin D and endothelial vasodilation in older individuals : Data from the PIVUS study. In: Journal of Clinical Endocrinology and Metabolism. 2014 ; Vol. 99, No. 9. pp. 3382-3389.
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abstract = "Context: Vitamin D plays a role in a wide range of extraskeletal processes, including vascular function. Endothelial dysfunction is a predictor of cardiovascular disease, especially in older subjects. However, the relationship between vitamin D levels and indexes of endothelial vasodilation has never been fully addressed in older individuals. CopyrightObjective: The objective of this study was to examine the association between vitamin D and endothelial function in a large community-based sample of older subjects.Methods: This cross-sectional study involved 852 community-dwelling men and women aged 70 years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), with complete data on vascular function and 25-hydroxyvitamin D. We evaluated endothelium-dependent vasodilation by an invasive forearm technique with acetylcholine, endothelium-independent vasodilation by sodium nitroprussiate, flow-mediated vasodilation, and the pulse wave analysis (reflectance index). Vitamin D levels were measured by chemiluminescence. We used multivariate regression models adjusted for body mass index (model 1) and for multiple confounders (high-sensitivity C-reactive protein, insulin, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein- cholesterol, smoking, sex hormones, season of blood collection, hypertension, diabetes, cardiovascular medications and diseases, statin usage, plasma calcium and calcium intake, PTH, physical exercise, liver and kidney function tests, albumin; model 2).Results: In women, but not in men, vitamin D levels were positively associated with endotheliumindependent vasodilation in both model 1 (β ± SE = 1.41 ± 0.54; P = .001), and model 2 (β ± SE = 2.01 ± 0.68; P = .003).We found no significant relationship between vitamin D levels and endothelium- dependent vasodilation, flow-mediated vasodilation, and reflectance index in both sexes.Conclusions: In older women, but not in men, vitamin D is positively and independently associated with EIDV.",
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T2 - Data from the PIVUS study

AU - Maggio, Marcello

AU - De Vita, Francesca

AU - Lauretani, Fulvio

AU - Ceda, Gian Paolo

AU - Volpi, Elena

AU - Giallauria, Francesco

AU - De Cicco, Giuseppe

AU - Cattabiani, Chiara

AU - Melhus, Håkan

AU - Michaëlsson, Karl

AU - Cederholm, Tommy

AU - Lind, Lars

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N2 - Context: Vitamin D plays a role in a wide range of extraskeletal processes, including vascular function. Endothelial dysfunction is a predictor of cardiovascular disease, especially in older subjects. However, the relationship between vitamin D levels and indexes of endothelial vasodilation has never been fully addressed in older individuals. CopyrightObjective: The objective of this study was to examine the association between vitamin D and endothelial function in a large community-based sample of older subjects.Methods: This cross-sectional study involved 852 community-dwelling men and women aged 70 years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), with complete data on vascular function and 25-hydroxyvitamin D. We evaluated endothelium-dependent vasodilation by an invasive forearm technique with acetylcholine, endothelium-independent vasodilation by sodium nitroprussiate, flow-mediated vasodilation, and the pulse wave analysis (reflectance index). Vitamin D levels were measured by chemiluminescence. We used multivariate regression models adjusted for body mass index (model 1) and for multiple confounders (high-sensitivity C-reactive protein, insulin, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein- cholesterol, smoking, sex hormones, season of blood collection, hypertension, diabetes, cardiovascular medications and diseases, statin usage, plasma calcium and calcium intake, PTH, physical exercise, liver and kidney function tests, albumin; model 2).Results: In women, but not in men, vitamin D levels were positively associated with endotheliumindependent vasodilation in both model 1 (β ± SE = 1.41 ± 0.54; P = .001), and model 2 (β ± SE = 2.01 ± 0.68; P = .003).We found no significant relationship between vitamin D levels and endothelium- dependent vasodilation, flow-mediated vasodilation, and reflectance index in both sexes.Conclusions: In older women, but not in men, vitamin D is positively and independently associated with EIDV.

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