TY - JOUR
T1 - Vitamin D and endothelial vasodilation in older individuals
T2 - Data from the PIVUS study
AU - Maggio, Marcello
AU - De Vita, Francesca
AU - Lauretani, Fulvio
AU - Ceda, Gian Paolo
AU - Volpi, Elena
AU - Giallauria, Francesco
AU - De Cicco, Giuseppe
AU - Cattabiani, Chiara
AU - Melhus, Håkan
AU - Michaëlsson, Karl
AU - Cederholm, Tommy
AU - Lind, Lars
N1 - Publisher Copyright:
© 2014 by the Endocrine Society.
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Context: Vitamin D plays a role in a wide range of extraskeletal processes, including vascular function. Endothelial dysfunction is a predictor of cardiovascular disease, especially in older subjects. However, the relationship between vitamin D levels and indexes of endothelial vasodilation has never been fully addressed in older individuals.Objective: The objective of this study was to examine the association between vitamin D and endothelial function in a large community-based sample of older subjects.Methods: This cross-sectional study involved 852 community-dwelling men and women aged 70 years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), with complete data on vascular function and 25-hydroxyvitamin D. We evaluated endothelium-dependent vasodilation by an invasive forearm technique with acetylcholine, endothelium-independent vasodilation by sodium nitroprussiate, flow-mediated vasodilation, and the pulse wave analysis (reflectance index). Vitamin D levels were measured by chemiluminescence. We used multivariate regression models adjusted for body mass index (model 1) and for multiple confounders (high-sensitivity C-reactive protein, insulin, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein- cholesterol, smoking, sex hormones, season of blood collection, hypertension, diabetes, cardiovascular medications and diseases, statin usage, plasma calcium and calcium intake, PTH, physical exercise, liver and kidney function tests, albumin; model 2).Conclusions: In older women, but not in men, vitamin D is positively and independently associated with EIDV.Results: In women, but not in men, vitamin D levels were positively associated with endotheliumindependent vasodilation in both model 1 (β ± SE = 1.41 ± 0.54; P = .001), and model 2 (β ± SE = 2.01 ± 0.68; P = .003).We found no significant relationship between vitamin D levels and endothelium- dependent vasodilation, flow-mediated vasodilation, and reflectance index in both sexes.
AB - Context: Vitamin D plays a role in a wide range of extraskeletal processes, including vascular function. Endothelial dysfunction is a predictor of cardiovascular disease, especially in older subjects. However, the relationship between vitamin D levels and indexes of endothelial vasodilation has never been fully addressed in older individuals.Objective: The objective of this study was to examine the association between vitamin D and endothelial function in a large community-based sample of older subjects.Methods: This cross-sectional study involved 852 community-dwelling men and women aged 70 years from the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS), with complete data on vascular function and 25-hydroxyvitamin D. We evaluated endothelium-dependent vasodilation by an invasive forearm technique with acetylcholine, endothelium-independent vasodilation by sodium nitroprussiate, flow-mediated vasodilation, and the pulse wave analysis (reflectance index). Vitamin D levels were measured by chemiluminescence. We used multivariate regression models adjusted for body mass index (model 1) and for multiple confounders (high-sensitivity C-reactive protein, insulin, total cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein- cholesterol, smoking, sex hormones, season of blood collection, hypertension, diabetes, cardiovascular medications and diseases, statin usage, plasma calcium and calcium intake, PTH, physical exercise, liver and kidney function tests, albumin; model 2).Conclusions: In older women, but not in men, vitamin D is positively and independently associated with EIDV.Results: In women, but not in men, vitamin D levels were positively associated with endotheliumindependent vasodilation in both model 1 (β ± SE = 1.41 ± 0.54; P = .001), and model 2 (β ± SE = 2.01 ± 0.68; P = .003).We found no significant relationship between vitamin D levels and endothelium- dependent vasodilation, flow-mediated vasodilation, and reflectance index in both sexes.
UR - https://www.scopus.com/pages/publications/84907223866
UR - https://www.scopus.com/pages/publications/84907223866#tab=citedBy
U2 - 10.1210/jc.2014-1536
DO - 10.1210/jc.2014-1536
M3 - Article
C2 - 24892991
AN - SCOPUS:84907223866
SN - 0021-972X
VL - 99
SP - 3382
EP - 3389
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 9
ER -