Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury

Naoki Morita, Katsumi Shimoda, Maret G. Traber, Martin Westphal, Perenlei Enkhbaatar, Kazunori Murakami, Scott W. Leonard, Lillian D. Traber, Daniel L. Traber

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Introduction: A decrease in α-tocopherol (vitamin E) plasma levels in burn patients is typically associated with increased mortality. We hypothesized that vitamin E supplementation (α-tocopherol) would attenuate acute lung injury induced by burn and smoke inhalation injury. Materials and methods: Under deep anesthesia, sheep (33 ± 5 kg) were subjected to a flame burn (40% total body surface area, third degree) and inhalation injury (48 breaths of cotton smoke, < 40°C). Half of the injured group received α-tocopherol (1000 IU vitamin E) orally, 24 h prior to injury. The sham group was neither injured nor given vitamin E. All three groups (n = 5 per group) were resuscitated with Ringer's lactate solution (4 ml/kg/%burn/24 h), and placed on a ventilator (PEEP = 5 cmH2O; tidal volume = 15 ml/ kg) for 48 h. Results: Plasma α-tocopherol per lipids doubled in the vitamin E treated sheep. Vitamin E treatment prior to injury largely prevented the increase in pulmonary permeability index and moderated the increase in lung lymph flow (52.6 ± 6.2 ml/min, compared with 27.3 ± 6.0 ml/min, respectively), increased the PaO2/FiO2 ratio, ameliorated both peak and pause airway pressure increases, and decreased plasma conjugated dienes and nitrotyrosine. Conclusions: Pretreatment with vitamin E ameliorated the acute lung injury caused by burn and smoke inhalation exposure.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalRedox Report
Issue number2
StatePublished - Apr 2006


  • Antioxidant
  • Inhalation injury
  • Oral administration
  • α-tocopherol

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical


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