Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury

Naoki Morita, Katsumi Shimoda, Maret G. Traber, Martin Westphal, Perenlei Enkhbaatar, Kazunori Murakami, Scott W. Leonard, Lillian D. Traber, Daniel L. Traber

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Introduction: A decrease in α-tocopherol (vitamin E) plasma levels in burn patients is typically associated with increased mortality. We hypothesized that vitamin E supplementation (α-tocopherol) would attenuate acute lung injury induced by burn and smoke inhalation injury. Materials and methods: Under deep anesthesia, sheep (33 ± 5 kg) were subjected to a flame burn (40% total body surface area, third degree) and inhalation injury (48 breaths of cotton smoke, < 40°C). Half of the injured group received α-tocopherol (1000 IU vitamin E) orally, 24 h prior to injury. The sham group was neither injured nor given vitamin E. All three groups (n = 5 per group) were resuscitated with Ringer's lactate solution (4 ml/kg/%burn/24 h), and placed on a ventilator (PEEP = 5 cmH2O; tidal volume = 15 ml/ kg) for 48 h. Results: Plasma α-tocopherol per lipids doubled in the vitamin E treated sheep. Vitamin E treatment prior to injury largely prevented the increase in pulmonary permeability index and moderated the increase in lung lymph flow (52.6 ± 6.2 ml/min, compared with 27.3 ± 6.0 ml/min, respectively), increased the PaO2/FiO2 ratio, ameliorated both peak and pause airway pressure increases, and decreased plasma conjugated dienes and nitrotyrosine. Conclusions: Pretreatment with vitamin E ameliorated the acute lung injury caused by burn and smoke inhalation exposure.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalRedox Report
Volume11
Issue number2
DOIs
StatePublished - Apr 2006

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Smoke Inhalation Injury
Acute Lung Injury
Vitamin E
Smoke
Sheep
Tocopherols
Plasmas
Wounds and Injuries
Inhalation Exposure
Lung
Body Surface Area
Tidal Volume
Lymph
Mechanical Ventilators
Burns
Inhalation
Cotton
Permeability
Anesthesia
Lipids

Keywords

  • α-tocopherol
  • Antioxidant
  • Inhalation injury
  • Oral administration

ASJC Scopus subject areas

  • Biochemistry

Cite this

Morita, N., Shimoda, K., Traber, M. G., Westphal, M., Enkhbaatar, P., Murakami, K., ... Traber, D. L. (2006). Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury. Redox Report, 11(2), 61-70. https://doi.org/10.1179/135100006X101020

Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury. / Morita, Naoki; Shimoda, Katsumi; Traber, Maret G.; Westphal, Martin; Enkhbaatar, Perenlei; Murakami, Kazunori; Leonard, Scott W.; Traber, Lillian D.; Traber, Daniel L.

In: Redox Report, Vol. 11, No. 2, 04.2006, p. 61-70.

Research output: Contribution to journalArticle

Morita, N, Shimoda, K, Traber, MG, Westphal, M, Enkhbaatar, P, Murakami, K, Leonard, SW, Traber, LD & Traber, DL 2006, 'Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury', Redox Report, vol. 11, no. 2, pp. 61-70. https://doi.org/10.1179/135100006X101020
Morita, Naoki ; Shimoda, Katsumi ; Traber, Maret G. ; Westphal, Martin ; Enkhbaatar, Perenlei ; Murakami, Kazunori ; Leonard, Scott W. ; Traber, Lillian D. ; Traber, Daniel L. / Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury. In: Redox Report. 2006 ; Vol. 11, No. 2. pp. 61-70.
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