Vitamin E improves cell-mediated immunity in the burned mouse: A preliminary study

Christine Rundus, Verlyn M. Peterson, Ramon Zapata Sirvent, John Hansbrough, William A. Robinson

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Profound immunosuppression occurs after major burn injuries. The ability of vitamin E to prevent post-burn immunosuppression was tested in mice using ear swelling in response to a challenge with 2,4-dinitrofluorobenzene (DNFB) as an in vivo measure of cell-mediated immunity (CMI). Vitamin E was administered to burned mice every other day for 14 days by either the topical or intraperitoneal route. Dimethyl sulphoxide (DMSO) was compared to white petroleum jelly (VAS) as a vehicle for topically administered vitamin E. Mean CMI±the standard error of the mean (SEM) was depressed to 55±4 per cent of normal control in untreated burned mice. Treatment with either parenteral vitamin E in corn oil or topical vitamin E in DMSO improved CMI dramatically compared to burned controls (P<0·005) while vitamin E in VAS had a less beneficial effect on CMI (P<0·05). We conclude that vitamin E is an effective immunomodulator in burned mice.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalBurns
Volume11
Issue number1
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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Vitamin E
Cellular Immunity
Dimethyl Sulfoxide
Immunosuppression
Dinitrofluorobenzene
Petrolatum
Corn Oil
Immunologic Factors
Burns
Ear
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery
  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Vitamin E improves cell-mediated immunity in the burned mouse : A preliminary study. / Rundus, Christine; Peterson, Verlyn M.; Zapata Sirvent, Ramon; Hansbrough, John; Robinson, William A.

In: Burns, Vol. 11, No. 1, 01.01.1984, p. 11-15.

Research output: Contribution to journalArticle

Rundus, Christine ; Peterson, Verlyn M. ; Zapata Sirvent, Ramon ; Hansbrough, John ; Robinson, William A. / Vitamin E improves cell-mediated immunity in the burned mouse : A preliminary study. In: Burns. 1984 ; Vol. 11, No. 1. pp. 11-15.
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