VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: Effects of sex and obesity

Bettina Mittendorfer, Bruce W. Patterson, Samuel Klein, Labros S. Sidossis

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Abstract

We have previously shown that sex and obesity independently affect basal very low density lipoprotein (VLDL)-triglyceride (TG) kinetics. In the present study, we investigated the effect of hyperglycemia-hyperinsulinemia on VLDL-TG kinetics in lean and obese men and women (n = 6 in each group). VLDL-TG kinetics were measured during basal, postabsorptive conditions and during glucose infusion (5.5 mg·kg FFM--1·min-1) by using [2H5]glycerol bolus injection in conjunction with compartmental modeling analysis. Basal VLDL-TG secretion in plasma was greater in obese than in lean men (7.8 ± 0.6 and 2.9 ± 0.4 μmol·l plasma-1·min-1; P < 0.001) but was not different in lean and obese women (5.0 ± 1.1 and 5.9 ± 1.1 μmol·l plasma-1·min-1). Glucose infusion decreased the VLDL-TG secretion rate by ∼50% in lean and obese men and in lean women (to 1.5 ± 0.4, 4.0 ± 0.6, and 2.2 ± 0.4 μmol·l plasma-1·min-1, respectively; all P < 0.05) but had no effect on the VLDL-TG secretion rate in obese women (4.9 ± 1.0 μmol·l plasma-1·min-1). These results demonstrate that both sex and adiposity affect the regulation of VLDL-TG metabolism. Glucose and insulin decrease VLDL-TG production in both lean men and lean women; obesity is associated with resistance to the glucose-and insulin-mediated suppression of VLDL-TG secretion in women, but not in men.

Original languageEnglish (US)
Pages (from-to)E708-E715
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume284
Issue number4 47-4
StatePublished - Apr 1 2003

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Keywords

  • Coronary heart disease
  • Hyperglycemia
  • Hypertriglyceridemia

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

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