Volume turnover kinetics of fluid shifts after hemorrhage, fluid infusion, and the combination of hemorrhage and fluid infusion in sheep

Åke Norberg, Kirk I. Brauer, Donald Prough, Johan Gabrielsson, Robert G. Hahn, Tatsuo Uchida, Daniel L. Traber, Christer H. Svensén

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background; Hemorrhage is commonly treated with intravenous infusion of crystalloids. However, the dynamics of fluid shifts between body fluid spaces are not completely known, causing contradictory recommendations regarding timing and volume of fluid infusions. The authors have developed a turnover model that characterizes these fluid shifts. Methods: Conscious, chronically instrumented sheep (n = 12) were randomly assigned to three protocol groups: infusion of 25 ml/kg of 0.9% saline over 20 min (infusion only), hemorrhage of 300 ml (7.8 ± 1.1 ml/kg) over 5 min (hemorrhage only), and hemorrhage of 300 ml over 5 min followed by infusion as noted above (hemorrhage plus infusion). A two-compartment volume turnover kinetic model containing seven model parameters was fitted to data obtained by repeated sampling of hemoglobin concentration and urinary excretion. Results: The volume turnover model successfully predicted fluid shifts. Mean baseline volumes of the central and tissue compartments were 1799 ± 1276 ml and 7653 ± 5478 ml, respectively. Immediate fluid infusion failed to prevent hemorrhage-induced depression of cardiac output and diuresis. The model suggested that volume recruitment to the central compartment after hemorrhage was primarily achieved by mechanisms other than volume equilibration between the two model compartments. Conclusion: Volume turnover kinetics is a promising tool for explaining fluid shifts between body compartments after perturbations such as hemorrhage and intravenous fluid infusions. The pronounced inhibition of renal output after hemorrhage prevailed regardless of fluid infusion and caused fluid retention, which expanded the tissue compartment.

Original languageEnglish
Pages (from-to)985-994
Number of pages10
JournalAnesthesiology
Volume102
Issue number5
DOIs
StatePublished - May 2005

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Fluid Shifts
Sheep
Hemorrhage
Intravenous Infusions
Diuresis
Body Fluids
Cardiac Output
Hemoglobins
Kidney

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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Volume turnover kinetics of fluid shifts after hemorrhage, fluid infusion, and the combination of hemorrhage and fluid infusion in sheep. / Norberg, Åke; Brauer, Kirk I.; Prough, Donald; Gabrielsson, Johan; Hahn, Robert G.; Uchida, Tatsuo; Traber, Daniel L.; Svensén, Christer H.

In: Anesthesiology, Vol. 102, No. 5, 05.2005, p. 985-994.

Research output: Contribution to journalArticle

Norberg, Åke ; Brauer, Kirk I. ; Prough, Donald ; Gabrielsson, Johan ; Hahn, Robert G. ; Uchida, Tatsuo ; Traber, Daniel L. ; Svensén, Christer H. / Volume turnover kinetics of fluid shifts after hemorrhage, fluid infusion, and the combination of hemorrhage and fluid infusion in sheep. In: Anesthesiology. 2005 ; Vol. 102, No. 5. pp. 985-994.
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