Voluntary ethanol consumption changes anticipatory ultrasonic vocalizations but not novelty response

Erik Garcia, Emily T. Jorgensen, Lukas S. Sprick, Mary E. Cain

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Novelty and sensation seeking (NSS) and affective disorders are correlated with earlier ethanol (ETOH) consumption, and sustained drinking into adulthood. Understanding the NSS response and affective response before and after voluntary ETOH consumption could elucidate important individual differences promoting sustained ETOH consumption. This study determined that NSS and affective response to rewarding stimulation—measured by ultrasonic vocalizations (USVs)—change after adolescent ETOH voluntary drinking. Rats were tested for their NSS response using the inescapable novelty test. Then rats were tested for their affective response to a natural reward and USVs were measured. The natural reward was experimenter-induced play behavior. Rats were exposed to ETOH for 8 weeks using an intermittent two bottle paradigm. After 8 weeks of voluntary consumption, rats were retested for their response to NSS and affective response to natural reward. Results indicate that voluntary ETOH consumption did not change the response to novelty. Control and ETOH exposed rats decreased their novelty response equally after ETOH consumption, suggesting the decrease was due to age. Importantly, voluntary ETOH consumption changed affective USVs. Compared to water-drinking control rats, ETOH-consuming rats elicited greater anticipatory trill USVs to a natural reward-associated context during a post-drinking probe test. Tickle-induced trill USVs did not change differently between ETOH and control rats. These results provide evidence that voluntary intermittent ETOH exposure increases the anticipation of reward and may represent a form of incentive salience. We postulate these diverging effects could be due to differences in incentive salience or reward processing. Together, these results suggest that voluntary ETOH consumption changes the affective response to conditioned and unconditioned natural rewards and offers a behavioral mechanism for studying affective reward processing after ETOH consumption.

Original languageEnglish (US)
Pages (from-to)186-194
Number of pages9
JournalBehavioural Brain Research
Volume320
DOIs
StatePublished - Mar 1 2017
Externally publishedYes

Fingerprint

Reward
Ultrasonics
Ethanol
Drinking
Motivation
Sensation Disorders
Mood Disorders
Individuality
Drinking Water

Keywords

  • Ethanol
  • Intermittent access
  • Novelty seeking
  • Reward processing
  • Ultrasonic vocalizations

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Voluntary ethanol consumption changes anticipatory ultrasonic vocalizations but not novelty response. / Garcia, Erik; Jorgensen, Emily T.; Sprick, Lukas S.; Cain, Mary E.

In: Behavioural Brain Research, Vol. 320, 01.03.2017, p. 186-194.

Research output: Contribution to journalArticle

Garcia, Erik ; Jorgensen, Emily T. ; Sprick, Lukas S. ; Cain, Mary E. / Voluntary ethanol consumption changes anticipatory ultrasonic vocalizations but not novelty response. In: Behavioural Brain Research. 2017 ; Vol. 320. pp. 186-194.
@article{8440e18c524949ad8bfb71f2ac49acb6,
title = "Voluntary ethanol consumption changes anticipatory ultrasonic vocalizations but not novelty response",
abstract = "Novelty and sensation seeking (NSS) and affective disorders are correlated with earlier ethanol (ETOH) consumption, and sustained drinking into adulthood. Understanding the NSS response and affective response before and after voluntary ETOH consumption could elucidate important individual differences promoting sustained ETOH consumption. This study determined that NSS and affective response to rewarding stimulation—measured by ultrasonic vocalizations (USVs)—change after adolescent ETOH voluntary drinking. Rats were tested for their NSS response using the inescapable novelty test. Then rats were tested for their affective response to a natural reward and USVs were measured. The natural reward was experimenter-induced play behavior. Rats were exposed to ETOH for 8 weeks using an intermittent two bottle paradigm. After 8 weeks of voluntary consumption, rats were retested for their response to NSS and affective response to natural reward. Results indicate that voluntary ETOH consumption did not change the response to novelty. Control and ETOH exposed rats decreased their novelty response equally after ETOH consumption, suggesting the decrease was due to age. Importantly, voluntary ETOH consumption changed affective USVs. Compared to water-drinking control rats, ETOH-consuming rats elicited greater anticipatory trill USVs to a natural reward-associated context during a post-drinking probe test. Tickle-induced trill USVs did not change differently between ETOH and control rats. These results provide evidence that voluntary intermittent ETOH exposure increases the anticipation of reward and may represent a form of incentive salience. We postulate these diverging effects could be due to differences in incentive salience or reward processing. Together, these results suggest that voluntary ETOH consumption changes the affective response to conditioned and unconditioned natural rewards and offers a behavioral mechanism for studying affective reward processing after ETOH consumption.",
keywords = "Ethanol, Intermittent access, Novelty seeking, Reward processing, Ultrasonic vocalizations",
author = "Erik Garcia and Jorgensen, {Emily T.} and Sprick, {Lukas S.} and Cain, {Mary E.}",
year = "2017",
month = "3",
day = "1",
doi = "10.1016/j.bbr.2016.12.004",
language = "English (US)",
volume = "320",
pages = "186--194",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",

}

TY - JOUR

T1 - Voluntary ethanol consumption changes anticipatory ultrasonic vocalizations but not novelty response

AU - Garcia, Erik

AU - Jorgensen, Emily T.

AU - Sprick, Lukas S.

AU - Cain, Mary E.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Novelty and sensation seeking (NSS) and affective disorders are correlated with earlier ethanol (ETOH) consumption, and sustained drinking into adulthood. Understanding the NSS response and affective response before and after voluntary ETOH consumption could elucidate important individual differences promoting sustained ETOH consumption. This study determined that NSS and affective response to rewarding stimulation—measured by ultrasonic vocalizations (USVs)—change after adolescent ETOH voluntary drinking. Rats were tested for their NSS response using the inescapable novelty test. Then rats were tested for their affective response to a natural reward and USVs were measured. The natural reward was experimenter-induced play behavior. Rats were exposed to ETOH for 8 weeks using an intermittent two bottle paradigm. After 8 weeks of voluntary consumption, rats were retested for their response to NSS and affective response to natural reward. Results indicate that voluntary ETOH consumption did not change the response to novelty. Control and ETOH exposed rats decreased their novelty response equally after ETOH consumption, suggesting the decrease was due to age. Importantly, voluntary ETOH consumption changed affective USVs. Compared to water-drinking control rats, ETOH-consuming rats elicited greater anticipatory trill USVs to a natural reward-associated context during a post-drinking probe test. Tickle-induced trill USVs did not change differently between ETOH and control rats. These results provide evidence that voluntary intermittent ETOH exposure increases the anticipation of reward and may represent a form of incentive salience. We postulate these diverging effects could be due to differences in incentive salience or reward processing. Together, these results suggest that voluntary ETOH consumption changes the affective response to conditioned and unconditioned natural rewards and offers a behavioral mechanism for studying affective reward processing after ETOH consumption.

AB - Novelty and sensation seeking (NSS) and affective disorders are correlated with earlier ethanol (ETOH) consumption, and sustained drinking into adulthood. Understanding the NSS response and affective response before and after voluntary ETOH consumption could elucidate important individual differences promoting sustained ETOH consumption. This study determined that NSS and affective response to rewarding stimulation—measured by ultrasonic vocalizations (USVs)—change after adolescent ETOH voluntary drinking. Rats were tested for their NSS response using the inescapable novelty test. Then rats were tested for their affective response to a natural reward and USVs were measured. The natural reward was experimenter-induced play behavior. Rats were exposed to ETOH for 8 weeks using an intermittent two bottle paradigm. After 8 weeks of voluntary consumption, rats were retested for their response to NSS and affective response to natural reward. Results indicate that voluntary ETOH consumption did not change the response to novelty. Control and ETOH exposed rats decreased their novelty response equally after ETOH consumption, suggesting the decrease was due to age. Importantly, voluntary ETOH consumption changed affective USVs. Compared to water-drinking control rats, ETOH-consuming rats elicited greater anticipatory trill USVs to a natural reward-associated context during a post-drinking probe test. Tickle-induced trill USVs did not change differently between ETOH and control rats. These results provide evidence that voluntary intermittent ETOH exposure increases the anticipation of reward and may represent a form of incentive salience. We postulate these diverging effects could be due to differences in incentive salience or reward processing. Together, these results suggest that voluntary ETOH consumption changes the affective response to conditioned and unconditioned natural rewards and offers a behavioral mechanism for studying affective reward processing after ETOH consumption.

KW - Ethanol

KW - Intermittent access

KW - Novelty seeking

KW - Reward processing

KW - Ultrasonic vocalizations

UR - http://www.scopus.com/inward/record.url?scp=85006105244&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006105244&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2016.12.004

DO - 10.1016/j.bbr.2016.12.004

M3 - Article

C2 - 27956212

AN - SCOPUS:85006105244

VL - 320

SP - 186

EP - 194

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

ER -