@article{a923de8fbbd94d57bdc785d60410f296,
title = "Water as a Direct Proton Source for Asymmetric Hydroarylation Catalyzed by a Rh(I)-Diene: Access to Nonproteinogenic β2/γ2/δ2-Amino Acid Derivatives",
abstract = "A highly enantioselective rhodium-catalyzed intermolecular hydroarylation of α-aminoalkyl acrylates using water as a direct proton source has been realized by employing a chiral bicyclo[3.3.0] diene ligand, allowing efficient access to a broad range of α-aryl-methyl-substituted β2-, γ2-, and δ2-amino esters with excellent enantioselectivities (up to 98% ee) under exceptionally mild conditions. By utilizing this method, a series of structurally interesting benzo-fused heterocyclic molecules and the corresponding β2-, γ2-, and δ2-amino acids are facilely constructed. ",
author = "Chen, {Jian Ping} and Yi Li and Chao Liu and Tianyi Wang and Chung, {Lung Wa} and Xu, {Ming Hua}",
note = "Funding Information: We thank the National Science & Technology Major Project “Key New Drug Creation and Manufacturing Program”, China (2018ZX09711002-006), the National Natural Science Foundation of China (21971103, 21672229, 81521005), and the Guangdong Provincial Key Laboratory of Catalysis (2020B121201002) for financial support. Funding Information: We thank the National Science & Technology Major Project {"}Key New Drug Creation and Manufacturing Program{"} China (2018ZX09711002-006), the National Natural Science Foundation of China (21971103, 21672229, 81521005), and the Guangdong Provincial Key Laboratory of Catalysis (2020B121201002) for financial support. Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",
year = "2021",
month = jan,
day = "15",
doi = "10.1021/acs.orglett.0c04099",
language = "English (US)",
volume = "23",
pages = "571--577",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "2",
}