Water content of gallstones: location and contribution to a hypothesis concerning stone structure

R. D. Soloway, E. B. Fayusal, B. W. Trotman, N. E. Weston, J. F. Ficca

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The water content of black pigment and cholesterol gallstones was evaluated with the use of moisture evolution analysis, electron spectroscopy for surface analysis, and X-ray diffraction. X-ray diffraction identified complex hydrated hydroxyapatite compounds in two stones. Moisture evolution analysis demonstrated that 18 pigment gallstones contained between 0.83 and 6.87% water; six cholesterol stones contained 0 to 0.27% (p<0.001). When black stones were subdivided into subgroups containing large proportions of pigment, phosphate, or carbonate, the proportion of water evolved at each temperature was the same. Water content was inversely related to carbonate content (r = -0.81) and did not correlate well with other stone components. Electron spectroscopy for surface analysis independently suggested that water of hydration was present since the ratio of oxygen to other elements exceeded ratios in any known compound in stone. A peripheral-central gradient for water was absent in one stone which was analyzed in peripheral mid-, and central portions. Progressive removal of the surface of previously ground stone particles using an argon beam followed by repeated electron spectroscopy for surface analysis indicated that much of the water was present in the outer 20 to 50 Å of the particles. The data are consistent with the hypothesis that pigment stones form by deposition of calcium salts on an organic matrix and that hydrated water is associated with thin layers of calcium salts. These layers may be distributed throughout the stone; powdering appears to fractionate stones through these areas of hydrated calcium salts since oxygen was in highest concentration on the surface of powder particles.

Original languageEnglish (US)
Pages (from-to)223-229
Number of pages7
JournalHepatology
Volume2
Issue number2
StatePublished - 1982
Externally publishedYes

Fingerprint

Gallstones
Water
Spectrum Analysis
Salts
Carbonates
Electrons
Calcium
X-Ray Diffraction
Cholesterol
Oxygen
Argon
Durapatite
Powders
Phosphates
Temperature

ASJC Scopus subject areas

  • Hepatology

Cite this

Soloway, R. D., Fayusal, E. B., Trotman, B. W., Weston, N. E., & Ficca, J. F. (1982). Water content of gallstones: location and contribution to a hypothesis concerning stone structure. Hepatology, 2(2), 223-229.

Water content of gallstones : location and contribution to a hypothesis concerning stone structure. / Soloway, R. D.; Fayusal, E. B.; Trotman, B. W.; Weston, N. E.; Ficca, J. F.

In: Hepatology, Vol. 2, No. 2, 1982, p. 223-229.

Research output: Contribution to journalArticle

Soloway, RD, Fayusal, EB, Trotman, BW, Weston, NE & Ficca, JF 1982, 'Water content of gallstones: location and contribution to a hypothesis concerning stone structure', Hepatology, vol. 2, no. 2, pp. 223-229.
Soloway RD, Fayusal EB, Trotman BW, Weston NE, Ficca JF. Water content of gallstones: location and contribution to a hypothesis concerning stone structure. Hepatology. 1982;2(2):223-229.
Soloway, R. D. ; Fayusal, E. B. ; Trotman, B. W. ; Weston, N. E. ; Ficca, J. F. / Water content of gallstones : location and contribution to a hypothesis concerning stone structure. In: Hepatology. 1982 ; Vol. 2, No. 2. pp. 223-229.
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