Water quality criteria assessment for chlorinated benzenes using the quantitative structure activity relation approach and porphyrogenic endpoint in rats

Norman M. Trieff, V-M Ramanujam

Research output: Contribution to journalArticlepeer-review

Abstract

Sub-chronic toxicity data on rats for various chlorobenzenes have been utilized to show a high correlation between log dose porphyria and log P, the log of the octanohwater partition coefficient. Various predictive equations were calculated as a function of log P, (log P)2, log P + (log P)2, log 1/Swand (log 1/S w )2. All have good correlations except for the case of (log 1/Sw)2. The calculated log criterion values obtained from predicted dose for porphyria in rats were regressed against log P and the log of the bioconcentration factor (log B) and various single and multi-parameter regression equations were found. Criteria predicted from log P values and sub-chronic toxicity data tended to be between 10–100 times larger than criteria calculated by other means (chronic toxicity, carcinogenicity or organoleptic). This quantitative structure activity relation approach has the advantage of providing criteria for all congeners in a series, whether or not they have been tested for carcinogenicity.

Original languageEnglish (US)
Pages (from-to)215-230
Number of pages16
JournalInternational Journal of Environmental Health Research
Volume1
Issue number4
DOIs
StatePublished - Dec 1 1991

Keywords

  • Chlorinated benzenes
  • porphyrogenicity
  • quantitative structure activity relations (QSAR)
  • water quality criteria

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pollution
  • Public Health, Environmental and Occupational Health

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