@inproceedings{422254ff492749b5b7c83ac3185df683,
title = "Wavelet differentiation of optoacoustic signals for monitoring of total hemoglobin concentration and oxygen saturation level in small blood vessels",
abstract = "We present a rapid, robust method of signal processing useful for optoacoustic monitoring of total hemoglobin concentration ([THb]) and oxygen saturation level in small blood vessels. Our method includes the wavelet-based regularization of the difference operator which is a typical discrete approximation of the derivative. The optimal degree of regularization is defined by the signal-to-noise ratio (SNR). We applied the proposed method to Monte Carlo-modeled signals from a cylinder simulating the human radial artery (diameter 1.6 mm, depth from skin 2 mm, and [THb] varied in a wide range from 4-16 g/dL). We obtained N-shaped signals and found that the maximum of the first derivative between the front and rear walls systematically correlates with the actual value of [THb]. We estimated the accuracy of [THb] reconstruction from the maximum of the first derivative as 0.32 ± 0.18 g/dL (mean value ±SD) at an SNR typical for our in vivo experiments at the wavelength of 1064 nm. We also demonstrated that the difference between the maxima of the first derivative of the signals obtained at 700 nm and 1000 nm depends on oxygen saturation level.",
keywords = "Monte Carlo, Optoacoustic monitoring, Signal processing",
author = "I. Patrikeev and Brecht, {H. P.} and Petrov, {Y. Y.} and Petrova, {I. Y.} and Prough, {D. S.} and Esenaliev, {R. O.}",
year = "2007",
doi = "10.1117/12.714185",
language = "English (US)",
isbn = "081946550X",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Photons Plus Ultrasound",
note = "Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics ; Conference date: 21-01-2007 Through 24-01-2007",
}