Wavelet differentiation of optoacoustic signals for monitoring of total hemoglobin concentration and oxygen saturation level in small blood vessels

I. Patrikeev, H. P. Brecht, Y. Y. Petrov, I. Y. Petrova, Donald Prough, Rinat Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

We present a rapid, robust method of signal processing useful for optoacoustic monitoring of total hemoglobin concentration ([THb]) and oxygen saturation level in small blood vessels. Our method includes the wavelet-based regularization of the difference operator which is a typical discrete approximation of the derivative. The optimal degree of regularization is defined by the signal-to-noise ratio (SNR). We applied the proposed method to Monte Carlo-modeled signals from a cylinder simulating the human radial artery (diameter 1.6 mm, depth from skin 2 mm, and [THb] varied in a wide range from 4-16 g/dL). We obtained N-shaped signals and found that the maximum of the first derivative between the front and rear walls systematically correlates with the actual value of [THb]. We estimated the accuracy of [THb] reconstruction from the maximum of the first derivative as 0.32 ± 0.18 g/dL (mean value ±SD) at an SNR typical for our in vivo experiments at the wavelength of 1064 nm. We also demonstrated that the difference between the maxima of the first derivative of the signals obtained at 700 nm and 1000 nm depends on oxygen saturation level.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6437
DOIs
StatePublished - 2007
EventPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - San Jose, CA, United States
Duration: Jan 21 2007Jan 24 2007

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
CountryUnited States
CitySan Jose, CA
Period1/21/071/24/07

Fingerprint

Photoacoustic effect
Hemoglobin
Blood vessels
Derivatives
Oxygen
Monitoring
Signal to noise ratio
Skin
Signal processing
Wavelength
Experiments

Keywords

  • Monte Carlo
  • Optoacoustic monitoring
  • Signal processing

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Patrikeev, I., Brecht, H. P., Petrov, Y. Y., Petrova, I. Y., Prough, D., & Esenaliev, R. (2007). Wavelet differentiation of optoacoustic signals for monitoring of total hemoglobin concentration and oxygen saturation level in small blood vessels. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6437). [643717] https://doi.org/10.1117/12.714185

Wavelet differentiation of optoacoustic signals for monitoring of total hemoglobin concentration and oxygen saturation level in small blood vessels. / Patrikeev, I.; Brecht, H. P.; Petrov, Y. Y.; Petrova, I. Y.; Prough, Donald; Esenaliev, Rinat.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6437 2007. 643717.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Patrikeev, I, Brecht, HP, Petrov, YY, Petrova, IY, Prough, D & Esenaliev, R 2007, Wavelet differentiation of optoacoustic signals for monitoring of total hemoglobin concentration and oxygen saturation level in small blood vessels. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6437, 643717, Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics, San Jose, CA, United States, 1/21/07. https://doi.org/10.1117/12.714185
Patrikeev I, Brecht HP, Petrov YY, Petrova IY, Prough D, Esenaliev R. Wavelet differentiation of optoacoustic signals for monitoring of total hemoglobin concentration and oxygen saturation level in small blood vessels. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6437. 2007. 643717 https://doi.org/10.1117/12.714185
Patrikeev, I. ; Brecht, H. P. ; Petrov, Y. Y. ; Petrova, I. Y. ; Prough, Donald ; Esenaliev, Rinat. / Wavelet differentiation of optoacoustic signals for monitoring of total hemoglobin concentration and oxygen saturation level in small blood vessels. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6437 2007.
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