Wavelet differentiation of optoacoustic signals for monitoring of total hemoglobin concentration and oxygen saturation level in small blood vessels

I. Patrikeev, H. P. Brecht, Y. Y. Petrov, I. Y. Petrova, D. S. Prough, R. O. Esenaliev

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

We present a rapid, robust method of signal processing useful for optoacoustic monitoring of total hemoglobin concentration ([THb]) and oxygen saturation level in small blood vessels. Our method includes the wavelet-based regularization of the difference operator which is a typical discrete approximation of the derivative. The optimal degree of regularization is defined by the signal-to-noise ratio (SNR). We applied the proposed method to Monte Carlo-modeled signals from a cylinder simulating the human radial artery (diameter 1.6 mm, depth from skin 2 mm, and [THb] varied in a wide range from 4-16 g/dL). We obtained N-shaped signals and found that the maximum of the first derivative between the front and rear walls systematically correlates with the actual value of [THb]. We estimated the accuracy of [THb] reconstruction from the maximum of the first derivative as 0.32 ± 0.18 g/dL (mean value ±SD) at an SNR typical for our in vivo experiments at the wavelength of 1064 nm. We also demonstrated that the difference between the maxima of the first derivative of the signals obtained at 700 nm and 1000 nm depends on oxygen saturation level.

Original languageEnglish (US)
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
DOIs
StatePublished - Apr 30 2007
EventPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - San Jose, CA, United States
Duration: Jan 21 2007Jan 24 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6437
ISSN (Print)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
CountryUnited States
CitySan Jose, CA
Period1/21/071/24/07

Keywords

  • Monte Carlo
  • Optoacoustic monitoring
  • Signal processing

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Patrikeev, I., Brecht, H. P., Petrov, Y. Y., Petrova, I. Y., Prough, D. S., & Esenaliev, R. O. (2007). Wavelet differentiation of optoacoustic signals for monitoring of total hemoglobin concentration and oxygen saturation level in small blood vessels. In Photons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics [643717] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6437). https://doi.org/10.1117/12.714185