@article{6a113179bfeb4700a500a9b2997a537e,
title = "Weight gain in early, mid, and late pregnancy and hypertensive disorders of pregnancy",
abstract = "Objective: To examine the relationship of weight change during early, mid, and late pregnancy with the development of a hypertensive disorder of pregnancy (HDP). Study design: These data are from a prospective cohort study of nulliparous women with live singleton pregnancies. “Early” weight change was defined as the difference between self-reported pre-pregnancy weight and weight at the first visit (between 6 and 13 weeks{\textquoteright} gestation); “mid” weight change was defined as the weight change between the first and second visits (between 16 and 21 weeks{\textquoteright} gestation); “late” weight change was defined as the weight change between the second and third visits (between 22 and 29 weeks{\textquoteright} gestation). Weight change in each time period was further characterized as inadequate, adequate, or excessive based on the Institute of Medicine's (IOM's) trimester-specific weekly weight gain goals based on pre-pregnancy body mass index. Multivariable Poisson regression was performed to adjust for potential confounders. Main outcome measure: Development of any hypertensive disorder of pregnancy. Results: Of 8296 women, 1564 (18.9%) developed a HDP. Weight gain in excess of the IOM recommendations during the latter two time periods was significantly associated with HDP. Specifically, trimester-specific excessive weight gain in the mid period (aIRR 1.16, 95% CI 1.01–1.35) as well as in the late period (aIRR = 1.19, 95% CI = 1.02–1.40) was associated with increased risk of developing HDP. The weight gain preceded the onset of clinically apparent disease. Conclusions: Excessive weight gain as early as the early second trimester was associated with increased risks of development of HDP.",
keywords = "Gestational weight gain, Hypertensive disorders, Preeclampsia, Pregnancy",
author = "Dude, {Annie M.} and Kominiarek, {Michelle A.} and Haas, {David M.} and Jay Iams and Mercer, {Brian M.} and Samuel Parry and Reddy, {Uma M.} and George Saade and Silver, {Robert M.} and Hyagriv Simhan and Ronald Wapner and Deborah Wing and William Grobman",
note = "Funding Information: Support for the NuMoM2b study was provided by grant funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development : U10 HD063036 , RTI International ; U10 HD063072 , Case Western Reserve University ; U10 HD063047 , Columbia University ; U10 HD063037 , Indiana University ; U10HD063041 , University of Pittsburgh ; U10 HD063020 , Northwestern University ; U10 HD063046 , University of California Irvine ; U10 HD063048 , University of Pennsylvania ; and U10 HD063053 , University of Utah . In addition, support was provided by respective Clinical and Translational Science Institutes to Indiana University (UL1TR001108) and University of California Irvine (UL1TR000153). The funding sources had no role in the study design, the collection/interpretation/analysis of these data, or the decision to submit this manuscript for publication. Funding Information: Support for the NuMoM2b study was provided by grant funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development: U10 HD063036, RTI International; U10 HD063072, Case Western Reserve University; U10 HD063047, Columbia University; U10 HD063037, Indiana University; U10HD063041, University of Pittsburgh; U10 HD063020, Northwestern University; U10 HD063046, University of California Irvine; U10 HD063048, University of Pennsylvania; and U10 HD063053, University of Utah. In addition, support was provided by respective Clinical and Translational Science Institutes to Indiana University (UL1TR001108) and University of California Irvine (UL1TR000153). The funding sources had no role in the study design, the collection/interpretation/analysis of these data, or the decision to submit this manuscript for publication. Publisher Copyright: {\textcopyright} 2020 International Society for the Study of Hypertension in Pregnancy",
year = "2020",
month = apr,
doi = "10.1016/j.preghy.2020.03.001",
language = "English (US)",
volume = "20",
pages = "50--55",
journal = "Pregnancy Hypertension",
issn = "2210-7789",
publisher = "Elsevier BV",
}