Weight gain in early, mid, and late pregnancy and hypertensive disorders of pregnancy

Annie M. Dude, Michelle A. Kominiarek, David M. Haas, Jay Iams, Brian M. Mercer, Samuel Parry, Uma M. Reddy, George Saade, Robert M. Silver, Hyagriv Simhan, Ronald Wapner, Deborah Wing, William Grobman

Research output: Contribution to journalArticle

Abstract

Objective: To examine the relationship of weight change during early, mid, and late pregnancy with the development of a hypertensive disorder of pregnancy (HDP). Study design: These data are from a prospective cohort study of nulliparous women with live singleton pregnancies. “Early” weight change was defined as the difference between self-reported pre-pregnancy weight and weight at the first visit (between 6 and 13 weeks’ gestation); “mid” weight change was defined as the weight change between the first and second visits (between 16 and 21 weeks’ gestation); “late” weight change was defined as the weight change between the second and third visits (between 22 and 29 weeks’ gestation). Weight change in each time period was further characterized as inadequate, adequate, or excessive based on the Institute of Medicine's (IOM's) trimester-specific weekly weight gain goals based on pre-pregnancy body mass index. Multivariable Poisson regression was performed to adjust for potential confounders. Main outcome measure: Development of any hypertensive disorder of pregnancy. Results: Of 8296 women, 1564 (18.9%) developed a HDP. Weight gain in excess of the IOM recommendations during the latter two time periods was significantly associated with HDP. Specifically, trimester-specific excessive weight gain in the mid period (aIRR 1.16, 95% CI 1.01–1.35) as well as in the late period (aIRR = 1.19, 95% CI = 1.02–1.40) was associated with increased risk of developing HDP. The weight gain preceded the onset of clinically apparent disease. Conclusions: Excessive weight gain as early as the early second trimester was associated with increased risks of development of HDP.

Original languageEnglish (US)
Pages (from-to)50-55
Number of pages6
JournalPregnancy hypertension
Volume20
DOIs
StatePublished - Apr 2020

Keywords

  • Gestational weight gain
  • Hypertensive disorders
  • Preeclampsia
  • Pregnancy

ASJC Scopus subject areas

  • Internal Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Weight gain in early, mid, and late pregnancy and hypertensive disorders of pregnancy'. Together they form a unique fingerprint.

  • Cite this

    Dude, A. M., Kominiarek, M. A., Haas, D. M., Iams, J., Mercer, B. M., Parry, S., Reddy, U. M., Saade, G., Silver, R. M., Simhan, H., Wapner, R., Wing, D., & Grobman, W. (2020). Weight gain in early, mid, and late pregnancy and hypertensive disorders of pregnancy. Pregnancy hypertension, 20, 50-55. https://doi.org/10.1016/j.preghy.2020.03.001