West Nile virus

Laura D. Kramer, Jun Li, Pei-Yong Shi

Research output: Contribution to journalArticle

199 Citations (Scopus)

Abstract

West Nile virus is a mosquito-borne flavivirus originally isolated in 1937 from the blood of a febrile woman in the West Nile province of Uganda. The virus is widely distributed in Africa, Europe, Australia, and Asia, and, since 1999, it has spread rapidly throughout the western hemisphere, including the USA, Canada, Mexico, and the Caribbean and into parts of Central and South America. Before 1994, outbreaks of West Nile virus were sporadic and occurred primarily in the Mediterranean region, Africa, and east Europe. Since 1994, outbreaks have occurred with a higher incidence of severe human disease, particularly affecting the nervous system. In North America, the virus has caused meningitis, encephalitis, and poliomyelitis, resulting in significant morbidity and mortality. The goal of this Review is to highlight recent advances in our understanding of West Nile virus virology, ecology, clinical disease, diagnosis, and development of potential vaccines and antiviral therapies.

Original languageEnglish (US)
Pages (from-to)171-181
Number of pages11
JournalLancet Neurology
Volume6
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

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West Nile virus
Disease Outbreaks
Mediterranean Region
Viruses
Flavivirus
Active Immunotherapy
Central America
Eastern Africa
Virology
Uganda
South America
Poliomyelitis
Encephalitis
North America
Mexico
Ecology
Culicidae
Meningitis
Nervous System
Canada

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

West Nile virus. / Kramer, Laura D.; Li, Jun; Shi, Pei-Yong.

In: Lancet Neurology, Vol. 6, No. 2, 02.2007, p. 171-181.

Research output: Contribution to journalArticle

Kramer, LD, Li, J & Shi, P-Y 2007, 'West Nile virus', Lancet Neurology, vol. 6, no. 2, pp. 171-181. https://doi.org/10.1016/S1474-4422(07)70030-3
Kramer, Laura D. ; Li, Jun ; Shi, Pei-Yong. / West Nile virus. In: Lancet Neurology. 2007 ; Vol. 6, No. 2. pp. 171-181.
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