West nile virus

Shannan Rossi, Ted M. Ross, Jared D. Evans

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

West Nile virus (WNV) is responsible for thousands of cases of morbidity and mortality in birds, horses, and humans. Epidemics were localized to Europe, Africa, the Middle East, and parts of Asia, and primarily caused a mild febrile illness in humans. In the late 1990s, the virus became more virulent and spread to North America. In humans, the clinical presentation ranges from asymptomatic, seen frequently, to encephalitis/paralysis and death, seen rarely. There is no FDA (Food and Drug Administration)-licensed vaccine for human use, and the only recommended treatment is supportive care. Often, there is a long recovery period. This article reviews the current literature summarizing the molecular virology, epidemiology, clinical manifestations, pathogenesis, diagnosis, treatment, immunology, and protective measures against WNV and WNV infections in humans.

Original languageEnglish (US)
Pages (from-to)47-65
Number of pages19
JournalClinics in Laboratory Medicine
Volume30
Issue number1
DOIs
StatePublished - Mar 2010
Externally publishedYes

Fingerprint

West Nile virus
Viruses
Immunology
Epidemiology
Birds
Virology
Middle East
Far East
Molecular Epidemiology
Virus Diseases
Encephalitis
United States Food and Drug Administration
North America
Allergy and Immunology
Vaccines
Paralysis
Horses
Recovery
Fever
Morbidity

Keywords

  • Diagnosis
  • Flavivirus
  • Infection
  • Pathogenesis
  • West Nile virus

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

West nile virus. / Rossi, Shannan; Ross, Ted M.; Evans, Jared D.

In: Clinics in Laboratory Medicine, Vol. 30, No. 1, 03.2010, p. 47-65.

Research output: Contribution to journalReview article

Rossi, Shannan ; Ross, Ted M. ; Evans, Jared D. / West nile virus. In: Clinics in Laboratory Medicine. 2010 ; Vol. 30, No. 1. pp. 47-65.
@article{5f3cb0bdfd624c53979545c4572c861b,
title = "West nile virus",
abstract = "West Nile virus (WNV) is responsible for thousands of cases of morbidity and mortality in birds, horses, and humans. Epidemics were localized to Europe, Africa, the Middle East, and parts of Asia, and primarily caused a mild febrile illness in humans. In the late 1990s, the virus became more virulent and spread to North America. In humans, the clinical presentation ranges from asymptomatic, seen frequently, to encephalitis/paralysis and death, seen rarely. There is no FDA (Food and Drug Administration)-licensed vaccine for human use, and the only recommended treatment is supportive care. Often, there is a long recovery period. This article reviews the current literature summarizing the molecular virology, epidemiology, clinical manifestations, pathogenesis, diagnosis, treatment, immunology, and protective measures against WNV and WNV infections in humans.",
keywords = "Diagnosis, Flavivirus, Infection, Pathogenesis, West Nile virus",
author = "Shannan Rossi and Ross, {Ted M.} and Evans, {Jared D.}",
year = "2010",
month = "3",
doi = "10.1016/j.cll.2009.10.006",
language = "English (US)",
volume = "30",
pages = "47--65",
journal = "Clinics in Laboratory Medicine",
issn = "0272-2712",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - West nile virus

AU - Rossi, Shannan

AU - Ross, Ted M.

AU - Evans, Jared D.

PY - 2010/3

Y1 - 2010/3

N2 - West Nile virus (WNV) is responsible for thousands of cases of morbidity and mortality in birds, horses, and humans. Epidemics were localized to Europe, Africa, the Middle East, and parts of Asia, and primarily caused a mild febrile illness in humans. In the late 1990s, the virus became more virulent and spread to North America. In humans, the clinical presentation ranges from asymptomatic, seen frequently, to encephalitis/paralysis and death, seen rarely. There is no FDA (Food and Drug Administration)-licensed vaccine for human use, and the only recommended treatment is supportive care. Often, there is a long recovery period. This article reviews the current literature summarizing the molecular virology, epidemiology, clinical manifestations, pathogenesis, diagnosis, treatment, immunology, and protective measures against WNV and WNV infections in humans.

AB - West Nile virus (WNV) is responsible for thousands of cases of morbidity and mortality in birds, horses, and humans. Epidemics were localized to Europe, Africa, the Middle East, and parts of Asia, and primarily caused a mild febrile illness in humans. In the late 1990s, the virus became more virulent and spread to North America. In humans, the clinical presentation ranges from asymptomatic, seen frequently, to encephalitis/paralysis and death, seen rarely. There is no FDA (Food and Drug Administration)-licensed vaccine for human use, and the only recommended treatment is supportive care. Often, there is a long recovery period. This article reviews the current literature summarizing the molecular virology, epidemiology, clinical manifestations, pathogenesis, diagnosis, treatment, immunology, and protective measures against WNV and WNV infections in humans.

KW - Diagnosis

KW - Flavivirus

KW - Infection

KW - Pathogenesis

KW - West Nile virus

UR - http://www.scopus.com/inward/record.url?scp=77953350230&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953350230&partnerID=8YFLogxK

U2 - 10.1016/j.cll.2009.10.006

DO - 10.1016/j.cll.2009.10.006

M3 - Review article

VL - 30

SP - 47

EP - 65

JO - Clinics in Laboratory Medicine

JF - Clinics in Laboratory Medicine

SN - 0272-2712

IS - 1

ER -