West Nile virus envelope protein role in diagnosis and immunity

Tian Wang, John F. Anderson, Louis A. Magnarelli, Sandra Bushmich, Susan Wong, Raymond A. Koski, Erol Fikrig

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The role of antibodies to the West Nile virus envelope (E) protein in serodiagnosis and protection was examined. The E protein was expressed and purified in recombinant form. Antibodies to the E protein were detected in patients with West Nile virus infection. Passive immunization with rabbit anti-E protein sera also partially protected mice from challenge with West Nile virus. The humoral response to the West Nile virus E protein is therefore useful as an aid in the diagnosis and may also play a role in immunity to infection.

Original languageEnglish (US)
Pages (from-to)325-327
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume951
StatePublished - 2001
Externally publishedYes

Fingerprint

Viral Envelope Proteins
West Nile virus
Viruses
Immunity
Proteins
Immunization
Passive Immunization
Antibodies
Serologic Tests
Virus Diseases
Blood Proteins
Rabbits
Protein
Nile
Virus
Infection

Keywords

  • E protein
  • Serologic tests
  • West Nile virus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Wang, T., Anderson, J. F., Magnarelli, L. A., Bushmich, S., Wong, S., Koski, R. A., & Fikrig, E. (2001). West Nile virus envelope protein role in diagnosis and immunity. Annals of the New York Academy of Sciences, 951, 325-327.

West Nile virus envelope protein role in diagnosis and immunity. / Wang, Tian; Anderson, John F.; Magnarelli, Louis A.; Bushmich, Sandra; Wong, Susan; Koski, Raymond A.; Fikrig, Erol.

In: Annals of the New York Academy of Sciences, Vol. 951, 2001, p. 325-327.

Research output: Contribution to journalArticle

Wang, T, Anderson, JF, Magnarelli, LA, Bushmich, S, Wong, S, Koski, RA & Fikrig, E 2001, 'West Nile virus envelope protein role in diagnosis and immunity', Annals of the New York Academy of Sciences, vol. 951, pp. 325-327.
Wang T, Anderson JF, Magnarelli LA, Bushmich S, Wong S, Koski RA et al. West Nile virus envelope protein role in diagnosis and immunity. Annals of the New York Academy of Sciences. 2001;951:325-327.
Wang, Tian ; Anderson, John F. ; Magnarelli, Louis A. ; Bushmich, Sandra ; Wong, Susan ; Koski, Raymond A. ; Fikrig, Erol. / West Nile virus envelope protein role in diagnosis and immunity. In: Annals of the New York Academy of Sciences. 2001 ; Vol. 951. pp. 325-327.
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