West Nile virus envelope protein role in diagnosis and immunity

Tian Wang, John F. Anderson, Louis A. Magnarelli, Sandra Bushmich, Susan Wong, Raymond A. Koski, Erol Fikrig

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

The role of antibodies to the West Nile virus envelope (E) protein in serodiagnosis and protection was examined. The E protein was expressed and purified in recombinant form. Antibodies to the E protein were detected in patients with West Nile virus infection. Passive immunization with rabbit anti-E protein sera also partially protected mice from challenge with West Nile virus. The humoral response to the West Nile virus E protein is therefore useful as an aid in the diagnosis and may also play a role in immunity to infection.

Original languageEnglish (US)
Pages (from-to)325-327
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume951
StatePublished - Jan 1 2001

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Keywords

  • E protein
  • Serologic tests
  • West Nile virus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Wang, T., Anderson, J. F., Magnarelli, L. A., Bushmich, S., Wong, S., Koski, R. A., & Fikrig, E. (2001). West Nile virus envelope protein role in diagnosis and immunity. Annals of the New York Academy of Sciences, 951, 325-327.