West Nile Virus Infection in the Central Nervous System

Tian Wang, Evandro R. Winkelmann, Huanle Luo

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide. Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae. Neither antiviral drugs nor vaccines are available for humans. Animal models have been used to investigate WNV pathogenesis and host immune response in humans. In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.

Original languageEnglish (US)
Article number105
JournalF1000Research
Volume5
DOIs
StatePublished - 2016

Fingerprint

West Nile virus
Neurology
Virus Diseases
Viruses
Central Nervous System
Animals
Animal Models
Flavivirus
Encephalitis
Antiviral Agents
Immunity
Vaccines

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

West Nile Virus Infection in the Central Nervous System. / Wang, Tian; Winkelmann, Evandro R.; Luo, Huanle.

In: F1000Research, Vol. 5, 105, 2016.

Research output: Contribution to journalReview article

Wang, Tian ; Winkelmann, Evandro R. ; Luo, Huanle. / West Nile Virus Infection in the Central Nervous System. In: F1000Research. 2016 ; Vol. 5.
@article{9b660e18d4954e38bf099d90d357fa18,
title = "West Nile Virus Infection in the Central Nervous System",
abstract = "West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide. Up to 50{\%} of WNV convalescent patients in the United States were reported to have long-term neurological sequelae. Neither antiviral drugs nor vaccines are available for humans. Animal models have been used to investigate WNV pathogenesis and host immune response in humans. In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.",
author = "Tian Wang and Winkelmann, {Evandro R.} and Huanle Luo",
year = "2016",
doi = "10.12688/f1000research.7404.1",
language = "English (US)",
volume = "5",
journal = "F1000Research",
issn = "2046-1402",
publisher = "F1000 Research Ltd.",

}

TY - JOUR

T1 - West Nile Virus Infection in the Central Nervous System

AU - Wang, Tian

AU - Winkelmann, Evandro R.

AU - Luo, Huanle

PY - 2016

Y1 - 2016

N2 - West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide. Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae. Neither antiviral drugs nor vaccines are available for humans. Animal models have been used to investigate WNV pathogenesis and host immune response in humans. In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.

AB - West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide. Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae. Neither antiviral drugs nor vaccines are available for humans. Animal models have been used to investigate WNV pathogenesis and host immune response in humans. In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.

UR - http://www.scopus.com/inward/record.url?scp=84970971273&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84970971273&partnerID=8YFLogxK

U2 - 10.12688/f1000research.7404.1

DO - 10.12688/f1000research.7404.1

M3 - Review article

VL - 5

JO - F1000Research

JF - F1000Research

SN - 2046-1402

M1 - 105

ER -