West Nile Virus Infection in the Central Nervous System

Tian Wang; Evandro R. Winkelmann; Huanle Luo

doi:10.12688/f1000research.7404.1

West Nile Virus Infection in the Central Nervous System

Tian Wang, Evandro R. Winkelmann, Huanle Luo

Microbiology And Immunology

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide. Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae. Neither antiviral drugs nor vaccines are available for humans. Animal models have been used to investigate WNV pathogenesis and host immune response in humans. In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.

Original language	English (US)
Article number	105
Journal	F1000Research
Volume	5
DOIs	https://doi.org/10.12688/f1000research.7404.1
State	Published - 2016

ASJC Scopus subject areas

General Immunology and Microbiology
General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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title = "West Nile Virus Infection in the Central Nervous System",

abstract = "West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide. Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae. Neither antiviral drugs nor vaccines are available for humans. Animal models have been used to investigate WNV pathogenesis and host immune response in humans. In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.",

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AU - Winkelmann, Evandro R.

AU - Luo, Huanle

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AB - West Nile virus (WNV), a neurotropic single-stranded flavivirus has been the leading cause of arboviral encephalitis worldwide. Up to 50% of WNV convalescent patients in the United States were reported to have long-term neurological sequelae. Neither antiviral drugs nor vaccines are available for humans. Animal models have been used to investigate WNV pathogenesis and host immune response in humans. In this review, we will discuss recent findings from studies in animal models of WNV infection, and provide new insights on WNV pathogenesis and WNV-induced host immunity in the central nervous system.

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West Nile Virus Infection in the Central Nervous System

Abstract

ASJC Scopus subject areas

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