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West Nile virus methyltransferase catalyzes two methylations of the viral RNA cap through a substrate-repositioning mechanism
Hongping Dong
, Suping Ren
, Bo Zhang
, Yangsheng Zhou
, Francesc Puig-Basagoiti
, Hongmin Li
, Pei Yong Shi
Biochemistry & Molecular Biology
Research output
:
Contribution to journal
›
Article
›
peer-review
100
Scopus citations
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Dive into the research topics of 'West Nile virus methyltransferase catalyzes two methylations of the viral RNA cap through a substrate-repositioning mechanism'. Together they form a unique fingerprint.
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Keyphrases
Pregenomic RNA (pgRNA)
100%
West Nile Virus
100%
Methylation
100%
S-adenosylmethionine
100%
Methyltransferase
100%
MRNA Cap
100%
Flavivirus
80%
Cap Hypermethylation
60%
Binding Site
40%
Binding Pocket
40%
GTP Binding
40%
2′-O-methylation
40%
Viral Replication
20%
Guanine
20%
Amino Acids
20%
Biochemical Analysis
20%
Adenosine
20%
Methyl Groups
20%
RNA Molecules
20%
RNA-binding Domain
20%
Methyltransferase Domain
20%
L-RNA
20%
Methyl Donors
20%
Replication Inhibitor
20%
Biochemistry, Genetics and Molecular Biology
RNA
100%
Methylation
100%
West Nile Virus
100%
Methyltransferase
100%
Methionine
62%
Flavivirus
50%
Binding Site
37%
Guanosine Triphosphate
37%
O-Methylation
25%
Virus Replication
12%
Crystal Structure
12%
Amino Acids
12%
RNA Binding
12%
Adenosine
12%
Guanine
12%