West Nile virus: Where are we now?

Bruno P. Granwehr, Kristy M. Lillibridge, Stephen Higgs, Peter W. Mason, Judith Aronson, Gerald Campbell, Alan Barrett

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

Since the publication of a comprehensive review on West Nile virus (WNV) in 2002, there has been substantial progress in understanding of transmission, epidemiology, and geographic distribution of the virus and manifestations of disease produced by the infection. There have also been advances in development of diagnostic and therapeutic agents and vaccines. Nevertheless, many questions about the epidemic remain unanswered, and several new issues have arisen - for example: whether the epidemic will increase as the virus spreads to the Pacific coast of North America; whether arthropods other than mosquitoes will act as vectors for the infection; whether WNV will spread to South America and cause an epidemic there; whether the distribution of WNV in Asia and Europe will increase; and whether adaptation of WNV to new ecosystems will produce viruses with altered genetic and phenotypic properties. This review aims to provide an update on knowledge of WNV biology that can be used to highlight the advances in the field during the past 2 years and help to define the questions that academic, industrial, and public-health communities must address in development of measures to control WNV disease.

Original languageEnglish (US)
Pages (from-to)547-556
Number of pages10
JournalLancet Infectious Diseases
Volume4
Issue number9
DOIs
StatePublished - Sep 1 2004

Fingerprint

West Nile virus
Virus Diseases
Viruses
Arthropods
South America
Occupational Health
North America
Infection
Culicidae
Ecosystem
Publications
Epidemiology
Vaccines
Public Health

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

West Nile virus : Where are we now? / Granwehr, Bruno P.; Lillibridge, Kristy M.; Higgs, Stephen; Mason, Peter W.; Aronson, Judith; Campbell, Gerald; Barrett, Alan.

In: Lancet Infectious Diseases, Vol. 4, No. 9, 01.09.2004, p. 547-556.

Research output: Contribution to journalArticle

Granwehr, Bruno P. ; Lillibridge, Kristy M. ; Higgs, Stephen ; Mason, Peter W. ; Aronson, Judith ; Campbell, Gerald ; Barrett, Alan. / West Nile virus : Where are we now?. In: Lancet Infectious Diseases. 2004 ; Vol. 4, No. 9. pp. 547-556.
@article{6bc6678379ba4870a2672b8c068d8617,
title = "West Nile virus: Where are we now?",
abstract = "Since the publication of a comprehensive review on West Nile virus (WNV) in 2002, there has been substantial progress in understanding of transmission, epidemiology, and geographic distribution of the virus and manifestations of disease produced by the infection. There have also been advances in development of diagnostic and therapeutic agents and vaccines. Nevertheless, many questions about the epidemic remain unanswered, and several new issues have arisen - for example: whether the epidemic will increase as the virus spreads to the Pacific coast of North America; whether arthropods other than mosquitoes will act as vectors for the infection; whether WNV will spread to South America and cause an epidemic there; whether the distribution of WNV in Asia and Europe will increase; and whether adaptation of WNV to new ecosystems will produce viruses with altered genetic and phenotypic properties. This review aims to provide an update on knowledge of WNV biology that can be used to highlight the advances in the field during the past 2 years and help to define the questions that academic, industrial, and public-health communities must address in development of measures to control WNV disease.",
author = "Granwehr, {Bruno P.} and Lillibridge, {Kristy M.} and Stephen Higgs and Mason, {Peter W.} and Judith Aronson and Gerald Campbell and Alan Barrett",
year = "2004",
month = "9",
day = "1",
doi = "10.1016/S1473-3099(04)01128-4",
language = "English (US)",
volume = "4",
pages = "547--556",
journal = "The Lancet Infectious Diseases",
issn = "1473-3099",
publisher = "Lancet Publishing Group",
number = "9",

}

TY - JOUR

T1 - West Nile virus

T2 - Where are we now?

AU - Granwehr, Bruno P.

AU - Lillibridge, Kristy M.

AU - Higgs, Stephen

AU - Mason, Peter W.

AU - Aronson, Judith

AU - Campbell, Gerald

AU - Barrett, Alan

PY - 2004/9/1

Y1 - 2004/9/1

N2 - Since the publication of a comprehensive review on West Nile virus (WNV) in 2002, there has been substantial progress in understanding of transmission, epidemiology, and geographic distribution of the virus and manifestations of disease produced by the infection. There have also been advances in development of diagnostic and therapeutic agents and vaccines. Nevertheless, many questions about the epidemic remain unanswered, and several new issues have arisen - for example: whether the epidemic will increase as the virus spreads to the Pacific coast of North America; whether arthropods other than mosquitoes will act as vectors for the infection; whether WNV will spread to South America and cause an epidemic there; whether the distribution of WNV in Asia and Europe will increase; and whether adaptation of WNV to new ecosystems will produce viruses with altered genetic and phenotypic properties. This review aims to provide an update on knowledge of WNV biology that can be used to highlight the advances in the field during the past 2 years and help to define the questions that academic, industrial, and public-health communities must address in development of measures to control WNV disease.

AB - Since the publication of a comprehensive review on West Nile virus (WNV) in 2002, there has been substantial progress in understanding of transmission, epidemiology, and geographic distribution of the virus and manifestations of disease produced by the infection. There have also been advances in development of diagnostic and therapeutic agents and vaccines. Nevertheless, many questions about the epidemic remain unanswered, and several new issues have arisen - for example: whether the epidemic will increase as the virus spreads to the Pacific coast of North America; whether arthropods other than mosquitoes will act as vectors for the infection; whether WNV will spread to South America and cause an epidemic there; whether the distribution of WNV in Asia and Europe will increase; and whether adaptation of WNV to new ecosystems will produce viruses with altered genetic and phenotypic properties. This review aims to provide an update on knowledge of WNV biology that can be used to highlight the advances in the field during the past 2 years and help to define the questions that academic, industrial, and public-health communities must address in development of measures to control WNV disease.

UR - http://www.scopus.com/inward/record.url?scp=4344647820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4344647820&partnerID=8YFLogxK

U2 - 10.1016/S1473-3099(04)01128-4

DO - 10.1016/S1473-3099(04)01128-4

M3 - Article

C2 - 15336221

AN - SCOPUS:4344647820

VL - 4

SP - 547

EP - 556

JO - The Lancet Infectious Diseases

JF - The Lancet Infectious Diseases

SN - 1473-3099

IS - 9

ER -