Western Equine Encephalitis submergence

Lack of evidence for a decline in virus virulence

Naomi L. Forrester, Joan L. Kenney, Eleanor Deardorff, Eryu Wang, Scott Weaver

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The incidence of Western Equine Encephalitis (WEE) in humans and equids peaked during the mid-20th century and has declined to fewer than 1-2 human cases annually during the past 20 years. Using the mouse model, changes in WEE virus (WEEV) virulence were investigated as a potential explanation for the decline in the number of cases. Evaluation of 10 WEEV strains representing a variety of isolation locations, hosts, and all decades from the 1940's to the 1990's yielded no evidence of a decline in virulence. These results suggest that ecological factors affecting human and equine exposure should be investigated to explain the decline in WEE.

Original languageEnglish (US)
Pages (from-to)170-172
Number of pages3
JournalVirology
Volume380
Issue number2
DOIs
StatePublished - Oct 25 2008

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Western Equine Encephalomyelitis
Western Equine Encephalitis Viruses
Virulence
Viruses
Horses
Incidence

Keywords

  • Virulence
  • Western Equine Encephalitis virus

ASJC Scopus subject areas

  • Virology

Cite this

Western Equine Encephalitis submergence : Lack of evidence for a decline in virus virulence. / Forrester, Naomi L.; Kenney, Joan L.; Deardorff, Eleanor; Wang, Eryu; Weaver, Scott.

In: Virology, Vol. 380, No. 2, 25.10.2008, p. 170-172.

Research output: Contribution to journalArticle

Forrester, Naomi L. ; Kenney, Joan L. ; Deardorff, Eleanor ; Wang, Eryu ; Weaver, Scott. / Western Equine Encephalitis submergence : Lack of evidence for a decline in virus virulence. In: Virology. 2008 ; Vol. 380, No. 2. pp. 170-172.
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