What are critical outcome measures for patients receiving pituitary replacement following brain injury?

Sorin G. Beca, Walter M. High, Brent E. Masel, Kurt A. Mossberg, Randall J. Urban

Research output: Contribution to journalReview article

5 Scopus citations


There are scant prospective studies defining improvements in critical outcome measures with hormone replacement in hypopituitarism secondary to brain injury. We review the tests of cognition and physical function and summarize their use for subjects that are deficient in anterior hormone production during anterior pituitary hormone replacement in brain injury and propose these as the minimal tests that are feasible for a physician to perform in a clinical setting. We summarize the studies conducted to assess outcome measures after brain injury and also report preliminary findings for improvements in cognition and physical function in subjects with brain injury and GH deficiency.

Original languageEnglish (US)
Pages (from-to)10-19
Number of pages10
Issue number1
StatePublished - Mar 1 2012



  • Brain injury
  • Cognitive function
  • Hypopituitarism
  • Physical function
  • Pituitary hormone replacement

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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