Where we stand with human hypertrophic and keloid scar models

Felicia N. Williams, David Herndon, Ludwik Branski

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

We have yet to create a human scar model that demonstrates the complex nature of hypertrophic scar and keloid formation as well as ways to prevent them despite emerging advances in our understanding of the immune system, the inflammatory response, and proteomic and genomic changes after injury. Despite more complex in vitro models, we fail to explain the fundamental principles to scar formation, and the timeline of their development. The solution to developing the ideal in vitro scar model is one that mimics the heterogeneous cellular and molecular interactions, as well as the evolving structure and function of human skin.

Original languageEnglish (US)
Pages (from-to)811-812
Number of pages2
JournalExperimental Dermatology
Volume23
Issue number11
DOIs
StatePublished - Nov 1 2014

Keywords

  • animal model
  • burn scar
  • inflammatory response
  • mesenchymal stem cell
  • skin

ASJC Scopus subject areas

  • Medicine(all)

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