WHO Working Group on technical specifications for manufacture and evaluation of dengue vaccines, Geneva, Switzerland, 11-12 May 2009

Dennis Trent, Jinho Shin, Joachim Hombach, Ivana Knezevic, Philip Minor

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

In May 2009, a group of international experts on dengue, vaccine quality and clinical evaluation met together (i) to review disease, vaccine pipeline, quality issues in manufacturing, issues of environmental risk assessment, nonclinical and clinical evaluation of live recombinant dengue vaccines and (ii) to initiate revising WHO guidelines for the production and quality control of candidate tetravalent dengue vaccines (live). This report summarizes an exchange of views on scientific and technical issues related to the quality, safety and efficacy of candidate dengue vaccines. Recognizing live dengue vaccines are the major vaccines in the clinical pipeline, the Working Group agreed (i) to focus on live dengue vaccines in the revision of the WHO guidelines and (ii) to add new guidelines on nonclinical and clinical evaluation, and environmental risk assessment for live dengue vaccines in the revision.

Original languageEnglish (US)
Pages (from-to)8246-8255
Number of pages10
JournalVaccine
Volume28
Issue number52
DOIs
StatePublished - Dec 6 2010

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Dengue Vaccines
dengue
Switzerland
manufacturing
vaccines
Guidelines
environmental assessment
Vaccines
Synthetic Vaccines
Quality Control
live vaccines
quality control
Safety

Keywords

  • Dengue vaccines
  • Evaluation
  • Standards
  • World Health Organization

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)
  • Molecular Medicine

Cite this

WHO Working Group on technical specifications for manufacture and evaluation of dengue vaccines, Geneva, Switzerland, 11-12 May 2009. / Trent, Dennis; Shin, Jinho; Hombach, Joachim; Knezevic, Ivana; Minor, Philip.

In: Vaccine, Vol. 28, No. 52, 06.12.2010, p. 8246-8255.

Research output: Contribution to journalArticle

Trent, Dennis ; Shin, Jinho ; Hombach, Joachim ; Knezevic, Ivana ; Minor, Philip. / WHO Working Group on technical specifications for manufacture and evaluation of dengue vaccines, Geneva, Switzerland, 11-12 May 2009. In: Vaccine. 2010 ; Vol. 28, No. 52. pp. 8246-8255.
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