Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels

Carrie A. Sailer; Gregory B. Pott; Charles A. Dinarello; Samantha Ma Whinney; Jeri E. Forster; Jacqueline K. Larson-Duran; Alan Landay; Lena Al-Harthi; Robert T. Schooley; Constance A. Benson; Franklyn N. Judson; Melanie Thompson; Frank J. Palella; Leland Shapiro

doi:10.1086/511435

Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels

Carrie A. Sailer, Gregory B. Pott, Charles A. Dinarello, Samantha Ma Whinney, Jeri E. Forster, Jacqueline K. Larson-Duran, Alan Landay, Lena Al-Harthi, Robert T. Schooley, Constance A. Benson, Franklyn N. Judson, Melanie Thompson, Frank J. Palella, Leland Shapiro

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Interleukin (IL)-18 generates T helper 1-type immunity and inhibits human immunodeficiency virus type 1 (HIV-1) in primary cells in vitro. Because IL-18 may participate in HIV-1 containment, whole-blood IL-18 levels were measured in 20 healthy control subjects and longitudinally in 28 subjects with early HIV-1 infection. Compared with those in control subjects, IL-18 levels were higher during early HIV-1 infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon (IFN)-γ levels. By contrast, a direct association between IL-18 and IFN-γ levels was observed in blood stimulated with lipopolysaccharide. During early HIV-1 infection, IL-18 may regulate HIV-1 coreceptor expression and have antiretroviral activity.

Original language	English (US)
Pages (from-to)	734-738
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	195
Issue number	5
DOIs	https://doi.org/10.1086/511435
State	Published - Mar 1 2007
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Sailer, C. A., Pott, G. B., Dinarello, C. A., Whinney, S. M., Forster, J. E., Larson-Duran, J. K., Landay, A., Al-Harthi, L., Schooley, R. T., Benson, C. A., Judson, F. N., Thompson, M., Palella, F. J., & Shapiro, L. (2007). Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels. Journal of Infectious Diseases, 195(5), 734-738. https://doi.org/10.1086/511435

Sailer, CA, Pott, GB, Dinarello, CA, Whinney, SM, Forster, JE, Larson-Duran, JK, Landay, A, Al-Harthi, L, Schooley, RT, Benson, CA, Judson, FN, Thompson, M, Palella, FJ & Shapiro, L 2007, 'Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels', Journal of Infectious Diseases, vol. 195, no. 5, pp. 734-738. https://doi.org/10.1086/511435

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title = "Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels",

abstract = "Interleukin (IL)-18 generates T helper 1-type immunity and inhibits human immunodeficiency virus type 1 (HIV-1) in primary cells in vitro. Because IL-18 may participate in HIV-1 containment, whole-blood IL-18 levels were measured in 20 healthy control subjects and longitudinally in 28 subjects with early HIV-1 infection. Compared with those in control subjects, IL-18 levels were higher during early HIV-1 infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon (IFN)-γ levels. By contrast, a direct association between IL-18 and IFN-γ levels was observed in blood stimulated with lipopolysaccharide. During early HIV-1 infection, IL-18 may regulate HIV-1 coreceptor expression and have antiretroviral activity.",

author = "Sailer, {Carrie A.} and Pott, {Gregory B.} and Dinarello, {Charles A.} and Whinney, {Samantha Ma} and Forster, {Jeri E.} and Larson-Duran, {Jacqueline K.} and Alan Landay and Lena Al-Harthi and Schooley, {Robert T.} and Benson, {Constance A.} and Judson, {Franklyn N.} and Melanie Thompson and Palella, {Frank J.} and Leland Shapiro",

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AU - Whinney, Samantha Ma

AU - Forster, Jeri E.

AU - Larson-Duran, Jacqueline K.

AU - Landay, Alan

AU - Al-Harthi, Lena

AU - Schooley, Robert T.

AU - Benson, Constance A.

AU - Judson, Franklyn N.

AU - Thompson, Melanie

AU - Palella, Frank J.

AU - Shapiro, Leland

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AB - Interleukin (IL)-18 generates T helper 1-type immunity and inhibits human immunodeficiency virus type 1 (HIV-1) in primary cells in vitro. Because IL-18 may participate in HIV-1 containment, whole-blood IL-18 levels were measured in 20 healthy control subjects and longitudinally in 28 subjects with early HIV-1 infection. Compared with those in control subjects, IL-18 levels were higher during early HIV-1 infection, and IL-18 levels predicted reduced CXCR4 HIV-1 coreceptor expression and diminished interferon (IFN)-γ levels. By contrast, a direct association between IL-18 and IFN-γ levels was observed in blood stimulated with lipopolysaccharide. During early HIV-1 infection, IL-18 may regulate HIV-1 coreceptor expression and have antiretroviral activity.

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Whole-blood interleukin-18 level during early HIV-1 infection is associated with reduced CXCR4 coreceptor expression and interferon-γ levels

Abstract

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