Abstract
Introduction: Cigarette smoking alters a variety of endocrine systems including thyroid hormones. Altered thyroid hormone signaling may lead to a subclinical or overt hypothyroid condition that could contribute to nicotine withdrawal-related symptoms, such as cognitive deficits. Thus, normalizing thyroid hormone levels may represent a novel therapeutic target for ameliorating nicotine withdrawal-associated cognitive deficits. Methods: The current studies conducted an analysis of serum thyroid hormone levels after chronic and withdrawal from chronic nicotine treatment in C57BL/6J mice using an enzyme-linked immunosorbent assay. The present studies also evaluated the effect of synthetic thyroid hormone (levothyroxine) on contextual and cued memory. Results: The current studies found that nicotine withdrawal reduces secreted thyroid hormone levels by 9% in C57BL/6J mice. Further, supplemental thyroid hormone not only enhanced memory in naïve animals, but also ameliorated deficits in hippocampus-dependent learning associated with nicotine withdrawal. Conclusions: These results suggest that smokers attempting to quit should be monitored closely for changes in thyroid function. If successfully treated, normalization of thyroid hormone levels may ameliorate some deficits associated with nicotine withdrawal and this may lead to higher rates of successful abstinence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 690-696 |
| Number of pages | 7 |
| Journal | Nicotine and Tobacco Research |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2015 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
Cite this
Withdrawal from chronic nicotine reduces thyroid hormone levels and levothyroxine treatment ameliorates nicotine withdrawal-induced deficits in hippocampus-dependent learning in C57BL/6J mice. / Leach, Prescott T.; Holliday, Erica; Kutlu, Munir G.; Gould, Thomas J.
In: Nicotine and Tobacco Research, Vol. 17, No. 6, 2015, p. 690-696.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Withdrawal from chronic nicotine reduces thyroid hormone levels and levothyroxine treatment ameliorates nicotine withdrawal-induced deficits in hippocampus-dependent learning in C57BL/6J mice
AU - Leach, Prescott T.
AU - Holliday, Erica
AU - Kutlu, Munir G.
AU - Gould, Thomas J.
PY - 2015
Y1 - 2015
N2 - Introduction: Cigarette smoking alters a variety of endocrine systems including thyroid hormones. Altered thyroid hormone signaling may lead to a subclinical or overt hypothyroid condition that could contribute to nicotine withdrawal-related symptoms, such as cognitive deficits. Thus, normalizing thyroid hormone levels may represent a novel therapeutic target for ameliorating nicotine withdrawal-associated cognitive deficits. Methods: The current studies conducted an analysis of serum thyroid hormone levels after chronic and withdrawal from chronic nicotine treatment in C57BL/6J mice using an enzyme-linked immunosorbent assay. The present studies also evaluated the effect of synthetic thyroid hormone (levothyroxine) on contextual and cued memory. Results: The current studies found that nicotine withdrawal reduces secreted thyroid hormone levels by 9% in C57BL/6J mice. Further, supplemental thyroid hormone not only enhanced memory in naïve animals, but also ameliorated deficits in hippocampus-dependent learning associated with nicotine withdrawal. Conclusions: These results suggest that smokers attempting to quit should be monitored closely for changes in thyroid function. If successfully treated, normalization of thyroid hormone levels may ameliorate some deficits associated with nicotine withdrawal and this may lead to higher rates of successful abstinence.
AB - Introduction: Cigarette smoking alters a variety of endocrine systems including thyroid hormones. Altered thyroid hormone signaling may lead to a subclinical or overt hypothyroid condition that could contribute to nicotine withdrawal-related symptoms, such as cognitive deficits. Thus, normalizing thyroid hormone levels may represent a novel therapeutic target for ameliorating nicotine withdrawal-associated cognitive deficits. Methods: The current studies conducted an analysis of serum thyroid hormone levels after chronic and withdrawal from chronic nicotine treatment in C57BL/6J mice using an enzyme-linked immunosorbent assay. The present studies also evaluated the effect of synthetic thyroid hormone (levothyroxine) on contextual and cued memory. Results: The current studies found that nicotine withdrawal reduces secreted thyroid hormone levels by 9% in C57BL/6J mice. Further, supplemental thyroid hormone not only enhanced memory in naïve animals, but also ameliorated deficits in hippocampus-dependent learning associated with nicotine withdrawal. Conclusions: These results suggest that smokers attempting to quit should be monitored closely for changes in thyroid function. If successfully treated, normalization of thyroid hormone levels may ameliorate some deficits associated with nicotine withdrawal and this may lead to higher rates of successful abstinence.
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UR - http://www.scopus.com/inward/citedby.url?scp=84942119342&partnerID=8YFLogxK
U2 - 10.1093/ntr/ntu229
DO - 10.1093/ntr/ntu229
M3 - Article
C2 - 25358661
AN - SCOPUS:84942119342
VL - 17
SP - 690
EP - 696
JO - Nicotine and Tobacco Research
JF - Nicotine and Tobacco Research
SN - 1462-2203
IS - 6
ER -