Wnt ligand expression in malignant melanoma: new insights

Khosrow Siamak Houschyar; Mimi R. Borrelli; Susanne Rein; Christian Tapking; Daniel Popp; Behrus Puladi; Mark Ooms; Torsten Schulz; Zeshaan N. Maan; Ludwik K. Branski; Frank Siemers; Wolfgang Gordon Philipp-Dormston; Amir S. Yazdi; Dominik Duscher

doi:10.1007/s00238-022-01941-6

Wnt ligand expression in malignant melanoma: new insights

Khosrow Siamak Houschyar, Mimi R. Borrelli, Susanne Rein, Christian Tapking, Daniel Popp, Behrus Puladi, Mark Ooms, Torsten Schulz, Zeshaan N. Maan, Ludwik K. Branski, Frank Siemers, Wolfgang Gordon Philipp-Dormston, Amir S. Yazdi, Dominik Duscher

Surgery

Research output: Contribution to journal › Review article › peer-review

Abstract

Cutaneous melanoma is the deadliest skin cancer and shows an increasing incidence. Survival rates of melanomas without metastases are high, but once metastases develop, mortality rates rise significantly. The Wnt/β catenin signaling plays an important role in tumorigenesis and critically regulates melanoma progression. In this review, we describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes involved in the development, homeostasis, and progression of malignant melanoma. Level of Evidence: Not gradable.

Original language	English (US)
Pages (from-to)	691-699
Number of pages	9
Journal	European Journal of Plastic Surgery
Volume	45
Issue number	5
DOIs	https://doi.org/10.1007/s00238-022-01941-6
State	Published - Oct 2022

Keywords

Carcinoma
Melanoma
Stem cells
Wnt signaling

ASJC Scopus subject areas

Surgery

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10.1007/s00238-022-01941-6

Cite this

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title = "Wnt ligand expression in malignant melanoma: new insights",

abstract = "Cutaneous melanoma is the deadliest skin cancer and shows an increasing incidence. Survival rates of melanomas without metastases are high, but once metastases develop, mortality rates rise significantly. The Wnt/β catenin signaling plays an important role in tumorigenesis and critically regulates melanoma progression. In this review, we describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes involved in the development, homeostasis, and progression of malignant melanoma. Level of Evidence: Not gradable.",

keywords = "Carcinoma, Melanoma, Stem cells, Wnt signaling",

author = "Houschyar, {Khosrow Siamak} and Borrelli, {Mimi R.} and Susanne Rein and Christian Tapking and Daniel Popp and Behrus Puladi and Mark Ooms and Torsten Schulz and Maan, {Zeshaan N.} and Branski, {Ludwik K.} and Frank Siemers and Philipp-Dormston, {Wolfgang Gordon} and Yazdi, {Amir S.} and Dominik Duscher",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2022",

month = oct,

doi = "10.1007/s00238-022-01941-6",

language = "English (US)",

volume = "45",

pages = "691--699",

journal = "European Journal of Plastic Surgery",

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TY - JOUR

T1 - Wnt ligand expression in malignant melanoma

T2 - new insights

AU - Houschyar, Khosrow Siamak

AU - Borrelli, Mimi R.

AU - Rein, Susanne

AU - Tapking, Christian

AU - Popp, Daniel

AU - Puladi, Behrus

AU - Ooms, Mark

AU - Schulz, Torsten

AU - Maan, Zeshaan N.

AU - Branski, Ludwik K.

AU - Siemers, Frank

AU - Philipp-Dormston, Wolfgang Gordon

AU - Yazdi, Amir S.

AU - Duscher, Dominik

PY - 2022/10

Y1 - 2022/10

N2 - Cutaneous melanoma is the deadliest skin cancer and shows an increasing incidence. Survival rates of melanomas without metastases are high, but once metastases develop, mortality rates rise significantly. The Wnt/β catenin signaling plays an important role in tumorigenesis and critically regulates melanoma progression. In this review, we describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes involved in the development, homeostasis, and progression of malignant melanoma. Level of Evidence: Not gradable.

AB - Cutaneous melanoma is the deadliest skin cancer and shows an increasing incidence. Survival rates of melanomas without metastases are high, but once metastases develop, mortality rates rise significantly. The Wnt/β catenin signaling plays an important role in tumorigenesis and critically regulates melanoma progression. In this review, we describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes involved in the development, homeostasis, and progression of malignant melanoma. Level of Evidence: Not gradable.

KW - Carcinoma

KW - Melanoma

KW - Stem cells

KW - Wnt signaling

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U2 - 10.1007/s00238-022-01941-6

DO - 10.1007/s00238-022-01941-6

M3 - Review article

AN - SCOPUS:85124474592

SN - 0930-343X

VL - 45

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EP - 699

JO - European Journal of Plastic Surgery

JF - European Journal of Plastic Surgery

IS - 5

ER -

Wnt ligand expression in malignant melanoma: new insights

Abstract

Keywords

ASJC Scopus subject areas

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