Wnt ligand expression in malignant melanoma: new insights

Khosrow Siamak Houschyar, Mimi R. Borrelli, Susanne Rein, Christian Tapking, Daniel Popp, Behrus Puladi, Mark Ooms, Torsten Schulz, Zeshaan N. Maan, Ludwik K. Branski, Frank Siemers, Wolfgang Gordon Philipp-Dormston, Amir S. Yazdi, Dominik Duscher

Research output: Contribution to journalReview articlepeer-review


Cutaneous melanoma is the deadliest skin cancer and shows an increasing incidence. Survival rates of melanomas without metastases are high, but once metastases develop, mortality rates rise significantly. The Wnt/β catenin signaling plays an important role in tumorigenesis and critically regulates melanoma progression. In this review, we describe the underlying mechanisms of Wnt signaling and outline how Wnt signaling controls cellular processes involved in the development, homeostasis, and progression of malignant melanoma. Level of Evidence: Not gradable.

Original languageEnglish (US)
Pages (from-to)691-699
Number of pages9
JournalEuropean Journal of Plastic Surgery
Issue number5
StatePublished - Oct 2022


  • Carcinoma
  • Melanoma
  • Stem cells
  • Wnt signaling

ASJC Scopus subject areas

  • Surgery


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