Wnt signaling: The good and the bad

Xi Chen; Jun Yang; Paul M. Evans; Chunming Liu

doi:10.1111/j.1745-7270.2008.00440.x

Wnt signaling: The good and the bad

Xi Chen, Jun Yang, Paul M. Evans, Chunming Liu

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

38 Scopus citations

Abstract

Since the first Wnt gene was identified in 1982, the functions and mechanisms of Wnt signaling have been extensively studied. Wnt signaling is conserved from invertebrates to vertebrates and regulates early embryonic development as well as the homeostasis of adult tissues. In addition, both embryonic stem cells and adult stem cells are regulated by Wnt signaling. Deregulation of Wnt signaling is associated with many human diseases, particularly cancers. In this review, we will discuss in detail the functions of many components involved in the Wnt signal transduction pathway. Then, we will explore what is known about the role of Wnt signaling in stem cells and cancers.

Original language	English (US)
Pages (from-to)	577-594
Number of pages	18
Journal	Acta Biochimica et Biophysica Sinica
Volume	40
Issue number	7
DOIs	https://doi.org/10.1111/j.1745-7270.2008.00440.x
State	Published - Jul 2008

Keywords

Cancer
Stem cell
Wnt signaling
β-catenin

ASJC Scopus subject areas

Biophysics
Biochemistry

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10.1111/j.1745-7270.2008.00440.x

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abstract = "Since the first Wnt gene was identified in 1982, the functions and mechanisms of Wnt signaling have been extensively studied. Wnt signaling is conserved from invertebrates to vertebrates and regulates early embryonic development as well as the homeostasis of adult tissues. In addition, both embryonic stem cells and adult stem cells are regulated by Wnt signaling. Deregulation of Wnt signaling is associated with many human diseases, particularly cancers. In this review, we will discuss in detail the functions of many components involved in the Wnt signal transduction pathway. Then, we will explore what is known about the role of Wnt signaling in stem cells and cancers.",

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AU - Yang, Jun

AU - Evans, Paul M.

AU - Liu, Chunming

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AB - Since the first Wnt gene was identified in 1982, the functions and mechanisms of Wnt signaling have been extensively studied. Wnt signaling is conserved from invertebrates to vertebrates and regulates early embryonic development as well as the homeostasis of adult tissues. In addition, both embryonic stem cells and adult stem cells are regulated by Wnt signaling. Deregulation of Wnt signaling is associated with many human diseases, particularly cancers. In this review, we will discuss in detail the functions of many components involved in the Wnt signal transduction pathway. Then, we will explore what is known about the role of Wnt signaling in stem cells and cancers.

KW - Cancer

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KW - Wnt signaling

KW - β-catenin

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Wnt signaling: The good and the bad

Abstract

Keywords

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