World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1

Update 2013 on the acute and continuation treatment of unipolar depressive disorders

Michael Bauer, Andrea Pfennig, Emanuel Severus, Peter C. Whybrow, Jules Angst, Hans Jürgen Möller, Mazda Adli, Otto Benkert, Tom Bschor, André Tadić, Edith Holsboer-Trachsler, Ian Anderson, David Baldwin, John C. Cookson, Heinz Grunze, Cornelius Katona, Eugene S. Paykel, Andre Tylee, José L. Ayuso-Gutierrez, Eduard Vieta & 38 others Per Bech, Rasmus W. Licht, Henrik Lublin, Per Vestergaard, Michael Berk, Graham Burrows, Philip B. Mitchell, Isaac Schweitzer, Istvan Bitter, Giovanni Cassano, Marcelo Cetkovich-Bakmas, Delcir Da Costa, Mihai D. Gheorghe, Gerardo Heinze, Teruhiko Higuchi, Robert M A Hirschfeld, Martin B. Keller, David J. Kupfer, A. John Rush, Jürgen Unützer, Cyril Höschl, Rhee Hun Kang, Min Soo Lee, Se Won Lim, Jong Woo Paik, Yong Chon Park, Siegfried Kasper, Selcuk Kirli, Aylin Yazici, E. Kostukova, Parmanand Kulhara, Brian Leonard, Odd Lingjaerde, Chia Yih Liu, Julien Mendlewicz, Stanislaw Puzynski, Janusz K. Rybakowski, Kazuo Yamada

Research output: Contribution to journalArticle

238 Citations (Scopus)

Abstract

Objectives. This 2013 update of the practice guidelines for the biological treatment of unipolar depressive disorders was developed by an international Task Force of the World Federation of Societies of Biological Psychiatry (WFSBP). The goal has been to systematically review all available evidence pertaining to the treatment of unipolar depressive disorders, and to produce a series of practice recommendations that are clinically and scientifically meaningful based on the available evidence. The guidelines are intended for use by all physicians seeing and treating patients with these conditions. Methods. The 2013 update was conducted by a systematic update literature search and appraisal. All recommendations were approved by the Guidelines Task Force. Results. This first part of the guidelines (Part 1) covers disease definition, classification, epidemiology, and course of unipolar depressive disorders, as well as the management of the acute and continuation phase treatment. It is primarily concerned with the biological treatment (including antidepressants, other psychopharmacological medications, electroconvulsive therapy, light therapy, adjunctive and novel therapeutic strategies) of adults. Conclusions. To date, there is a variety of evidence-based antidepressant treatment options available. Nevertheless there is still a substantial proportion of patients not achieving full remission. In addition, somatic and psychiatric comorbidities and other special circumstances need to be more thoroughly investigated. Therefore, further high-quality informative randomized controlled trials are urgently needed.

Original languageEnglish (US)
Pages (from-to)334-385
Number of pages52
JournalWorld Journal of Biological Psychiatry
Volume14
Issue number5
DOIs
StatePublished - Jul 2013

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Biological Psychiatry
Depressive Disorder
Guidelines
Advisory Committees
Antidepressive Agents
Therapeutics
Electroconvulsive Therapy
Phototherapy
Practice Guidelines
Psychiatry
Comorbidity
Epidemiology
Randomized Controlled Trials
Physicians

Keywords

  • Acute treatment
  • Antidepressants
  • Continuation treatment
  • Major depressive disorder
  • Pharmacotherapy

ASJC Scopus subject areas

  • Biological Psychiatry
  • Psychiatry and Mental health

Cite this

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1 : Update 2013 on the acute and continuation treatment of unipolar depressive disorders. / Bauer, Michael; Pfennig, Andrea; Severus, Emanuel; Whybrow, Peter C.; Angst, Jules; Möller, Hans Jürgen; Adli, Mazda; Benkert, Otto; Bschor, Tom; Tadić, André; Holsboer-Trachsler, Edith; Anderson, Ian; Baldwin, David; Cookson, John C.; Grunze, Heinz; Katona, Cornelius; Paykel, Eugene S.; Tylee, Andre; Ayuso-Gutierrez, José L.; Vieta, Eduard; Bech, Per; Licht, Rasmus W.; Lublin, Henrik; Vestergaard, Per; Berk, Michael; Burrows, Graham; Mitchell, Philip B.; Schweitzer, Isaac; Bitter, Istvan; Cassano, Giovanni; Cetkovich-Bakmas, Marcelo; Da Costa, Delcir; Gheorghe, Mihai D.; Heinze, Gerardo; Higuchi, Teruhiko; Hirschfeld, Robert M A; Keller, Martin B.; Kupfer, David J.; Rush, A. John; Unützer, Jürgen; Höschl, Cyril; Kang, Rhee Hun; Lee, Min Soo; Lim, Se Won; Paik, Jong Woo; Park, Yong Chon; Kasper, Siegfried; Kirli, Selcuk; Yazici, Aylin; Kostukova, E.; Kulhara, Parmanand; Leonard, Brian; Lingjaerde, Odd; Liu, Chia Yih; Mendlewicz, Julien; Puzynski, Stanislaw; Rybakowski, Janusz K.; Yamada, Kazuo.

In: World Journal of Biological Psychiatry, Vol. 14, No. 5, 07.2013, p. 334-385.

Research output: Contribution to journalArticle

Bauer, M, Pfennig, A, Severus, E, Whybrow, PC, Angst, J, Möller, HJ, Adli, M, Benkert, O, Bschor, T, Tadić, A, Holsboer-Trachsler, E, Anderson, I, Baldwin, D, Cookson, JC, Grunze, H, Katona, C, Paykel, ES, Tylee, A, Ayuso-Gutierrez, JL, Vieta, E, Bech, P, Licht, RW, Lublin, H, Vestergaard, P, Berk, M, Burrows, G, Mitchell, PB, Schweitzer, I, Bitter, I, Cassano, G, Cetkovich-Bakmas, M, Da Costa, D, Gheorghe, MD, Heinze, G, Higuchi, T, Hirschfeld, RMA, Keller, MB, Kupfer, DJ, Rush, AJ, Unützer, J, Höschl, C, Kang, RH, Lee, MS, Lim, SW, Paik, JW, Park, YC, Kasper, S, Kirli, S, Yazici, A, Kostukova, E, Kulhara, P, Leonard, B, Lingjaerde, O, Liu, CY, Mendlewicz, J, Puzynski, S, Rybakowski, JK & Yamada, K 2013, 'World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1: Update 2013 on the acute and continuation treatment of unipolar depressive disorders', World Journal of Biological Psychiatry, vol. 14, no. 5, pp. 334-385. https://doi.org/10.3109/15622975.2013.804195
Bauer, Michael ; Pfennig, Andrea ; Severus, Emanuel ; Whybrow, Peter C. ; Angst, Jules ; Möller, Hans Jürgen ; Adli, Mazda ; Benkert, Otto ; Bschor, Tom ; Tadić, André ; Holsboer-Trachsler, Edith ; Anderson, Ian ; Baldwin, David ; Cookson, John C. ; Grunze, Heinz ; Katona, Cornelius ; Paykel, Eugene S. ; Tylee, Andre ; Ayuso-Gutierrez, José L. ; Vieta, Eduard ; Bech, Per ; Licht, Rasmus W. ; Lublin, Henrik ; Vestergaard, Per ; Berk, Michael ; Burrows, Graham ; Mitchell, Philip B. ; Schweitzer, Isaac ; Bitter, Istvan ; Cassano, Giovanni ; Cetkovich-Bakmas, Marcelo ; Da Costa, Delcir ; Gheorghe, Mihai D. ; Heinze, Gerardo ; Higuchi, Teruhiko ; Hirschfeld, Robert M A ; Keller, Martin B. ; Kupfer, David J. ; Rush, A. John ; Unützer, Jürgen ; Höschl, Cyril ; Kang, Rhee Hun ; Lee, Min Soo ; Lim, Se Won ; Paik, Jong Woo ; Park, Yong Chon ; Kasper, Siegfried ; Kirli, Selcuk ; Yazici, Aylin ; Kostukova, E. ; Kulhara, Parmanand ; Leonard, Brian ; Lingjaerde, Odd ; Liu, Chia Yih ; Mendlewicz, Julien ; Puzynski, Stanislaw ; Rybakowski, Janusz K. ; Yamada, Kazuo. / World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1 : Update 2013 on the acute and continuation treatment of unipolar depressive disorders. In: World Journal of Biological Psychiatry. 2013 ; Vol. 14, No. 5. pp. 334-385.
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abstract = "Objectives. This 2013 update of the practice guidelines for the biological treatment of unipolar depressive disorders was developed by an international Task Force of the World Federation of Societies of Biological Psychiatry (WFSBP). The goal has been to systematically review all available evidence pertaining to the treatment of unipolar depressive disorders, and to produce a series of practice recommendations that are clinically and scientifically meaningful based on the available evidence. The guidelines are intended for use by all physicians seeing and treating patients with these conditions. Methods. The 2013 update was conducted by a systematic update literature search and appraisal. All recommendations were approved by the Guidelines Task Force. Results. This first part of the guidelines (Part 1) covers disease definition, classification, epidemiology, and course of unipolar depressive disorders, as well as the management of the acute and continuation phase treatment. It is primarily concerned with the biological treatment (including antidepressants, other psychopharmacological medications, electroconvulsive therapy, light therapy, adjunctive and novel therapeutic strategies) of adults. Conclusions. To date, there is a variety of evidence-based antidepressant treatment options available. Nevertheless there is still a substantial proportion of patients not achieving full remission. In addition, somatic and psychiatric comorbidities and other special circumstances need to be more thoroughly investigated. Therefore, further high-quality informative randomized controlled trials are urgently needed.",
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T1 - World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1

T2 - Update 2013 on the acute and continuation treatment of unipolar depressive disorders

AU - Bauer, Michael

AU - Pfennig, Andrea

AU - Severus, Emanuel

AU - Whybrow, Peter C.

AU - Angst, Jules

AU - Möller, Hans Jürgen

AU - Adli, Mazda

AU - Benkert, Otto

AU - Bschor, Tom

AU - Tadić, André

AU - Holsboer-Trachsler, Edith

AU - Anderson, Ian

AU - Baldwin, David

AU - Cookson, John C.

AU - Grunze, Heinz

AU - Katona, Cornelius

AU - Paykel, Eugene S.

AU - Tylee, Andre

AU - Ayuso-Gutierrez, José L.

AU - Vieta, Eduard

AU - Bech, Per

AU - Licht, Rasmus W.

AU - Lublin, Henrik

AU - Vestergaard, Per

AU - Berk, Michael

AU - Burrows, Graham

AU - Mitchell, Philip B.

AU - Schweitzer, Isaac

AU - Bitter, Istvan

AU - Cassano, Giovanni

AU - Cetkovich-Bakmas, Marcelo

AU - Da Costa, Delcir

AU - Gheorghe, Mihai D.

AU - Heinze, Gerardo

AU - Higuchi, Teruhiko

AU - Hirschfeld, Robert M A

AU - Keller, Martin B.

AU - Kupfer, David J.

AU - Rush, A. John

AU - Unützer, Jürgen

AU - Höschl, Cyril

AU - Kang, Rhee Hun

AU - Lee, Min Soo

AU - Lim, Se Won

AU - Paik, Jong Woo

AU - Park, Yong Chon

AU - Kasper, Siegfried

AU - Kirli, Selcuk

AU - Yazici, Aylin

AU - Kostukova, E.

AU - Kulhara, Parmanand

AU - Leonard, Brian

AU - Lingjaerde, Odd

AU - Liu, Chia Yih

AU - Mendlewicz, Julien

AU - Puzynski, Stanislaw

AU - Rybakowski, Janusz K.

AU - Yamada, Kazuo

PY - 2013/7

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KW - Acute treatment

KW - Antidepressants

KW - Continuation treatment

KW - Major depressive disorder

KW - Pharmacotherapy

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