X-linked B lymphocyte deficiency. I. Panhypo-γ-globulinemia and dys-γ-globulinemia in siblings

Randall M. Goldblum, Ralph A. Lord, Max D. Cooper, William E. Gathings, Armond S. Goldman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In two families with x-linked B lymphocyte deficiency, siblings were found to have either panhypo-γ-globulinemia or dys-γ-globulinemia. Despite differences in serum immunoglobulin patterns and severity of symptoms, a marked deficiency in surface immunoglobulin-bearing lymphocytes occurred in all affected males. These studies suggest that the primary defect in these patients is in the development of circulating B lymphocytes and that normal levels of serum IgA and IgD can be attained despite this deficiency.

Original languageEnglish (US)
Pages (from-to)188-191
Number of pages4
JournalThe Journal of pediatrics
Volume85
Issue number2
DOIs
StatePublished - 1974

Fingerprint

Siblings
B-Lymphocytes
Immunoglobulin D
B-Cell Antigen Receptors
Serum
Immunoglobulin A
Immunoglobulins
Lymphocytes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

X-linked B lymphocyte deficiency. I. Panhypo-γ-globulinemia and dys-γ-globulinemia in siblings. / Goldblum, Randall M.; Lord, Ralph A.; Cooper, Max D.; Gathings, William E.; Goldman, Armond S.

In: The Journal of pediatrics, Vol. 85, No. 2, 1974, p. 188-191.

Research output: Contribution to journalArticle

Goldblum, Randall M. ; Lord, Ralph A. ; Cooper, Max D. ; Gathings, William E. ; Goldman, Armond S. / X-linked B lymphocyte deficiency. I. Panhypo-γ-globulinemia and dys-γ-globulinemia in siblings. In: The Journal of pediatrics. 1974 ; Vol. 85, No. 2. pp. 188-191.
@article{62fe68fc52f74f88b2e6ca28cd38e597,
title = "X-linked B lymphocyte deficiency. I. Panhypo-γ-globulinemia and dys-γ-globulinemia in siblings",
abstract = "In two families with x-linked B lymphocyte deficiency, siblings were found to have either panhypo-γ-globulinemia or dys-γ-globulinemia. Despite differences in serum immunoglobulin patterns and severity of symptoms, a marked deficiency in surface immunoglobulin-bearing lymphocytes occurred in all affected males. These studies suggest that the primary defect in these patients is in the development of circulating B lymphocytes and that normal levels of serum IgA and IgD can be attained despite this deficiency.",
author = "Goldblum, {Randall M.} and Lord, {Ralph A.} and Cooper, {Max D.} and Gathings, {William E.} and Goldman, {Armond S.}",
year = "1974",
doi = "10.1016/S0022-3476(74)80390-2",
language = "English (US)",
volume = "85",
pages = "188--191",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - X-linked B lymphocyte deficiency. I. Panhypo-γ-globulinemia and dys-γ-globulinemia in siblings

AU - Goldblum, Randall M.

AU - Lord, Ralph A.

AU - Cooper, Max D.

AU - Gathings, William E.

AU - Goldman, Armond S.

PY - 1974

Y1 - 1974

N2 - In two families with x-linked B lymphocyte deficiency, siblings were found to have either panhypo-γ-globulinemia or dys-γ-globulinemia. Despite differences in serum immunoglobulin patterns and severity of symptoms, a marked deficiency in surface immunoglobulin-bearing lymphocytes occurred in all affected males. These studies suggest that the primary defect in these patients is in the development of circulating B lymphocytes and that normal levels of serum IgA and IgD can be attained despite this deficiency.

AB - In two families with x-linked B lymphocyte deficiency, siblings were found to have either panhypo-γ-globulinemia or dys-γ-globulinemia. Despite differences in serum immunoglobulin patterns and severity of symptoms, a marked deficiency in surface immunoglobulin-bearing lymphocytes occurred in all affected males. These studies suggest that the primary defect in these patients is in the development of circulating B lymphocytes and that normal levels of serum IgA and IgD can be attained despite this deficiency.

UR - http://www.scopus.com/inward/record.url?scp=0016172190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016172190&partnerID=8YFLogxK

U2 - 10.1016/S0022-3476(74)80390-2

DO - 10.1016/S0022-3476(74)80390-2

M3 - Article

C2 - 4210296

AN - SCOPUS:0016172190

VL - 85

SP - 188

EP - 191

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

IS - 2

ER -