X-linked B lymphocyte deficiency. I. Panhypo-γ-globulinemia and dys-γ-globulinemia in siblings

Randall M. Goldblum, Ralph A. Lord, Max D. Cooper, William E. Gathings, Armond S. Goldman

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

In two families with x-linked B lymphocyte deficiency, siblings were found to have either panhypo-γ-globulinemia or dys-γ-globulinemia. Despite differences in serum immunoglobulin patterns and severity of symptoms, a marked deficiency in surface immunoglobulin-bearing lymphocytes occurred in all affected males. These studies suggest that the primary defect in these patients is in the development of circulating B lymphocytes and that normal levels of serum IgA and IgD can be attained despite this deficiency.

Original languageEnglish (US)
Pages (from-to)188-191
Number of pages4
JournalThe Journal of Pediatrics
Volume85
Issue number2
DOIs
StatePublished - Aug 1974

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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