Xenoestrogens are potent activators of nongenomic estrogenic responses

Cheryl S. Watson, Nataliya N. Bulayeva, Ann L. Wozniak, Rebecca A. Alyea

    Research output: Contribution to journalArticle

    112 Citations (Scopus)

    Abstract

    Studies of the nuclear transcriptional regulatory activities of non-physiological estrogens have not explained their actions in mediating endocrine disruption in animals and humans at the low concentrations widespread in the environment. However, xenoestrogens have rarely been tested for their ability to participate in the plethora of nongenomic steroid signaling pathways elucidated over the last several years. Here we review what is known about such responses in comparison to our recent evidence that xenoestrogens can rapidly and potently elicit signaling through nongenomic pathways culminating in functional endpoints. Both estradiol (E2) and compounds representing various classes of xenoestrogens (diethylstilbestrol, coumestrol, bisphenol A, DDE, nonylphenol, endosulfan, and dieldrin) act via a membrane version of the estrogen receptor-α on pituitary cells, and can provoke Ca2+ influx via L-type channels, leading to prolactin (PRL) secretion. These hormones and mimetics can also cause the oscillating activation of extracellular regulated kinases (ERKs). However, individual estrogen mimetics differ in their potency and temporal phasing of these activations compared to each other and to E2. It is perhaps in these ways that they disrupt some endocrine functions when acting in combination with physiological estrogens. Our quantitative assays allow comparison of these outcomes for each mimetic, and let us build a detailed picture of alternative signaling pathway usage. Such an understanding should allow us to determine the estrogenic or antiestrogenic potential of different types of xenoestrogens, and help us to develop strategies for preventing xenoestrogenic disruption of estrogen action in many tissues.

    Original languageEnglish (US)
    Pages (from-to)124-134
    Number of pages11
    JournalSteroids
    Volume72
    Issue number2
    DOIs
    StatePublished - Feb 2007

    Fingerprint

    Estrogens
    Coumestrol
    Chemical activation
    Endosulfan
    Dieldrin
    Dichlorodiphenyl Dichloroethylene
    Diethylstilbestrol
    Estrogen Receptors
    Prolactin
    Estradiol
    Assays
    Animals
    Phosphotransferases
    Steroids
    Hormones
    Tissue
    Membranes

    Keywords

    • Calcium
    • Environmental estrogen
    • Kinases
    • Low concentrations
    • Membrane
    • Prolactin

    ASJC Scopus subject areas

    • Biochemistry
    • Endocrinology
    • Molecular Biology

    Cite this

    Watson, C. S., Bulayeva, N. N., Wozniak, A. L., & Alyea, R. A. (2007). Xenoestrogens are potent activators of nongenomic estrogenic responses. Steroids, 72(2), 124-134. https://doi.org/10.1016/j.steroids.2006.11.002

    Xenoestrogens are potent activators of nongenomic estrogenic responses. / Watson, Cheryl S.; Bulayeva, Nataliya N.; Wozniak, Ann L.; Alyea, Rebecca A.

    In: Steroids, Vol. 72, No. 2, 02.2007, p. 124-134.

    Research output: Contribution to journalArticle

    Watson, CS, Bulayeva, NN, Wozniak, AL & Alyea, RA 2007, 'Xenoestrogens are potent activators of nongenomic estrogenic responses', Steroids, vol. 72, no. 2, pp. 124-134. https://doi.org/10.1016/j.steroids.2006.11.002
    Watson, Cheryl S. ; Bulayeva, Nataliya N. ; Wozniak, Ann L. ; Alyea, Rebecca A. / Xenoestrogens are potent activators of nongenomic estrogenic responses. In: Steroids. 2007 ; Vol. 72, No. 2. pp. 124-134.
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