Xenon/computed tomography cerebral blood flow measurements methods and accuracy

Panos P. Fatouros; Abund O. Wist; P. Kishore; Deuglas S. Dbwitt; James A. Hall; Richard L. Keenan; Lauraine M. Stewart; Anthony Marmarou; Sung C. Choi; Hermes A. Kontos

doi:10.1097/00004424-198709000-00003

Xenon/computed tomography cerebral blood flow measurements methods and accuracy

Panos P. Fatouros, Abund O. Wist, P. Kishore, Deuglas S. Dbwitt, James A. Hall, Richard L. Keenan, Lauraine M. Stewart, Anthony Marmarou, Sung C. Choi, Hermes A. Kontos

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

We performed a series of five baboon experiments to compare cerebral blood flow measured with an improved stable xenon/CT method and the radiolabelled microsphere technique at a PaC02 of 40 mm Hg. The xenon/CT method was implemented by fitting the arterial xenon uptake with a double exponential function, by measuring the oxygen and carbon dioxide concentrations continuously during each breath and by taking into account the lung-to- brain transit time of xenon. The time of xenon inhalation was extended to 30 minutes to obtain more reliable estimates of CBF in white matter regions. The results indicate an overall correlation coefficient of 0.92 between the two methods and good numeric agreement.

Original language	English (US)
Pages (from-to)	705-712
Number of pages	8
Journal	Investigative radiology
Volume	22
Issue number	9
DOIs	https://doi.org/10.1097/00004424-198709000-00003
State	Published - Sep 1987
Externally published	Yes

Keywords

Cerebral blool flow
Radiolabeled microspheres
Xenon/CT

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1097/00004424-198709000-00003

Cite this

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title = "Xenon/computed tomography cerebral blood flow measurements methods and accuracy",

abstract = "We performed a series of five baboon experiments to compare cerebral blood flow measured with an improved stable xenon/CT method and the radiolabelled microsphere technique at a PaC02 of 40 mm Hg. The xenon/CT method was implemented by fitting the arterial xenon uptake with a double exponential function, by measuring the oxygen and carbon dioxide concentrations continuously during each breath and by taking into account the lung-to- brain transit time of xenon. The time of xenon inhalation was extended to 30 minutes to obtain more reliable estimates of CBF in white matter regions. The results indicate an overall correlation coefficient of 0.92 between the two methods and good numeric agreement.",

keywords = "Cerebral blool flow, Radiolabeled microspheres, Xenon/CT",

author = "Fatouros, {Panos P.} and Wist, {Abund O.} and P. Kishore and Dbwitt, {Deuglas S.} and Hall, {James A.} and Keenan, {Richard L.} and Stewart, {Lauraine M.} and Anthony Marmarou and Choi, {Sung C.} and Kontos, {Hermes A.}",

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language = "English (US)",

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T1 - Xenon/computed tomography cerebral blood flow measurements methods and accuracy

AU - Fatouros, Panos P.

AU - Wist, Abund O.

AU - Kishore, P.

AU - Dbwitt, Deuglas S.

AU - Hall, James A.

AU - Keenan, Richard L.

AU - Stewart, Lauraine M.

AU - Marmarou, Anthony

AU - Choi, Sung C.

AU - Kontos, Hermes A.

PY - 1987/9

Y1 - 1987/9

N2 - We performed a series of five baboon experiments to compare cerebral blood flow measured with an improved stable xenon/CT method and the radiolabelled microsphere technique at a PaC02 of 40 mm Hg. The xenon/CT method was implemented by fitting the arterial xenon uptake with a double exponential function, by measuring the oxygen and carbon dioxide concentrations continuously during each breath and by taking into account the lung-to- brain transit time of xenon. The time of xenon inhalation was extended to 30 minutes to obtain more reliable estimates of CBF in white matter regions. The results indicate an overall correlation coefficient of 0.92 between the two methods and good numeric agreement.

AB - We performed a series of five baboon experiments to compare cerebral blood flow measured with an improved stable xenon/CT method and the radiolabelled microsphere technique at a PaC02 of 40 mm Hg. The xenon/CT method was implemented by fitting the arterial xenon uptake with a double exponential function, by measuring the oxygen and carbon dioxide concentrations continuously during each breath and by taking into account the lung-to- brain transit time of xenon. The time of xenon inhalation was extended to 30 minutes to obtain more reliable estimates of CBF in white matter regions. The results indicate an overall correlation coefficient of 0.92 between the two methods and good numeric agreement.

KW - Cerebral blool flow

KW - Radiolabeled microspheres

KW - Xenon/CT

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JO - Investigative radiology

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Xenon/computed tomography cerebral blood flow measurements methods and accuracy

Abstract

Keywords

ASJC Scopus subject areas

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