Xenon/computed tomography cerebral blood flow measurements. Methods and accuracy

P. P. Fatouros, A. O. Wist, P. R S Kishore, Douglas Dewitt, J. A. Hall, R. L. Keenan, L. M. Stewart, A. Marmarou, S. C. Choi, H. A. Kontos

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We performed a series of five baboon experiments to compare cerebral blood flow measured with an improved stable xenon/CT method and the radiolabelled microsphere technique at a PaCO2 of 40 mm Hg. The xenon/CT method was implemented by fitting the arterial xenon uptake with a double exponential function, by measuring the oxygen and carbon dioxide concentrations continuously during each breath and by taking into account the lung-to-brain transit time of xenon. The time of xenon inhalation was extended to 30 minutes to obtain more reliable estimates of CBF in white matter regions. The results indicate an overall correlation coefficient of 0.92 between the two methods and good numeric agreement.

Original languageEnglish (US)
Pages (from-to)705-712
Number of pages8
JournalInvestigative Radiology
Volume22
Issue number9
StatePublished - 1987
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Xenon
Tomography
Papio
Microspheres
Carbon Dioxide
Inhalation
Oxygen
Lung
Brain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Fatouros, P. P., Wist, A. O., Kishore, P. R. S., Dewitt, D., Hall, J. A., Keenan, R. L., ... Kontos, H. A. (1987). Xenon/computed tomography cerebral blood flow measurements. Methods and accuracy. Investigative Radiology, 22(9), 705-712.

Xenon/computed tomography cerebral blood flow measurements. Methods and accuracy. / Fatouros, P. P.; Wist, A. O.; Kishore, P. R S; Dewitt, Douglas; Hall, J. A.; Keenan, R. L.; Stewart, L. M.; Marmarou, A.; Choi, S. C.; Kontos, H. A.

In: Investigative Radiology, Vol. 22, No. 9, 1987, p. 705-712.

Research output: Contribution to journalArticle

Fatouros, PP, Wist, AO, Kishore, PRS, Dewitt, D, Hall, JA, Keenan, RL, Stewart, LM, Marmarou, A, Choi, SC & Kontos, HA 1987, 'Xenon/computed tomography cerebral blood flow measurements. Methods and accuracy', Investigative Radiology, vol. 22, no. 9, pp. 705-712.
Fatouros PP, Wist AO, Kishore PRS, Dewitt D, Hall JA, Keenan RL et al. Xenon/computed tomography cerebral blood flow measurements. Methods and accuracy. Investigative Radiology. 1987;22(9):705-712.
Fatouros, P. P. ; Wist, A. O. ; Kishore, P. R S ; Dewitt, Douglas ; Hall, J. A. ; Keenan, R. L. ; Stewart, L. M. ; Marmarou, A. ; Choi, S. C. ; Kontos, H. A. / Xenon/computed tomography cerebral blood flow measurements. Methods and accuracy. In: Investigative Radiology. 1987 ; Vol. 22, No. 9. pp. 705-712.
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