YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

Boon Chuan Low, Catherine Qiurong Pan, G. V. Shivashankar, Alexander Bershadsky, Marius Sudol, Michael Sheetz

Research output: Contribution to journalReview article

164 Citations (Scopus)

Abstract

Organ size is controlled by the concerted action of biochemical and physical processes. Although mechanical forces are known to regulate cell and tissue behavior, as well as organogenesis, the precise molecular events that integrate mechanical and biochemical signals to control these processes are not fully known. The recently delineated Hippo-tumor suppressor network and its two nuclear effectors, YAP and TAZ, shed light on these mechanisms. YAP and TAZ are proto-oncogene proteins that respond to complex physical milieu represented by the rigidity of the extracellular matrix, cell geometry, cell density, cell polarity and the status of the actin cytoskeleton. Here, we review the current knowledge of how YAP and TAZ function as mechanosensors and mechanotransducers. We also suggest that by deciphering the mechanical and biochemical signals controlling YAP/TAZ function, we will gain insights into new strategies for cancer treatment and organ regeneration.

Original languageEnglish (US)
Pages (from-to)2663-2670
Number of pages8
JournalFEBS Letters
Volume588
Issue number16
DOIs
StatePublished - Aug 19 2014
Externally publishedYes

Fingerprint

Organ Size
Proto-Oncogene Proteins
Tumors
Biochemical Phenomena
Physical Phenomena
Cell Polarity
Oncology
Organogenesis
Growth
Actin Cytoskeleton
Rigidity
Extracellular Matrix
Actins
Regeneration
Neoplasms
Cell Count
Tissue
Geometry

Keywords

  • Hippo tumor suppressor
  • Mechanosensor
  • Mechanotransducer
  • Organ size
  • YAP/TAZ

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth. / Low, Boon Chuan; Pan, Catherine Qiurong; Shivashankar, G. V.; Bershadsky, Alexander; Sudol, Marius; Sheetz, Michael.

In: FEBS Letters, Vol. 588, No. 16, 19.08.2014, p. 2663-2670.

Research output: Contribution to journalReview article

Low, Boon Chuan ; Pan, Catherine Qiurong ; Shivashankar, G. V. ; Bershadsky, Alexander ; Sudol, Marius ; Sheetz, Michael. / YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth. In: FEBS Letters. 2014 ; Vol. 588, No. 16. pp. 2663-2670.
@article{2255720e62a44cba8e296f33577a0cc0,
title = "YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth",
abstract = "Organ size is controlled by the concerted action of biochemical and physical processes. Although mechanical forces are known to regulate cell and tissue behavior, as well as organogenesis, the precise molecular events that integrate mechanical and biochemical signals to control these processes are not fully known. The recently delineated Hippo-tumor suppressor network and its two nuclear effectors, YAP and TAZ, shed light on these mechanisms. YAP and TAZ are proto-oncogene proteins that respond to complex physical milieu represented by the rigidity of the extracellular matrix, cell geometry, cell density, cell polarity and the status of the actin cytoskeleton. Here, we review the current knowledge of how YAP and TAZ function as mechanosensors and mechanotransducers. We also suggest that by deciphering the mechanical and biochemical signals controlling YAP/TAZ function, we will gain insights into new strategies for cancer treatment and organ regeneration.",
keywords = "Hippo tumor suppressor, Mechanosensor, Mechanotransducer, Organ size, YAP/TAZ",
author = "Low, {Boon Chuan} and Pan, {Catherine Qiurong} and Shivashankar, {G. V.} and Alexander Bershadsky and Marius Sudol and Michael Sheetz",
year = "2014",
month = "8",
day = "19",
doi = "10.1016/j.febslet.2014.04.012",
language = "English (US)",
volume = "588",
pages = "2663--2670",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "Elsevier",
number = "16",

}

TY - JOUR

T1 - YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

AU - Low, Boon Chuan

AU - Pan, Catherine Qiurong

AU - Shivashankar, G. V.

AU - Bershadsky, Alexander

AU - Sudol, Marius

AU - Sheetz, Michael

PY - 2014/8/19

Y1 - 2014/8/19

N2 - Organ size is controlled by the concerted action of biochemical and physical processes. Although mechanical forces are known to regulate cell and tissue behavior, as well as organogenesis, the precise molecular events that integrate mechanical and biochemical signals to control these processes are not fully known. The recently delineated Hippo-tumor suppressor network and its two nuclear effectors, YAP and TAZ, shed light on these mechanisms. YAP and TAZ are proto-oncogene proteins that respond to complex physical milieu represented by the rigidity of the extracellular matrix, cell geometry, cell density, cell polarity and the status of the actin cytoskeleton. Here, we review the current knowledge of how YAP and TAZ function as mechanosensors and mechanotransducers. We also suggest that by deciphering the mechanical and biochemical signals controlling YAP/TAZ function, we will gain insights into new strategies for cancer treatment and organ regeneration.

AB - Organ size is controlled by the concerted action of biochemical and physical processes. Although mechanical forces are known to regulate cell and tissue behavior, as well as organogenesis, the precise molecular events that integrate mechanical and biochemical signals to control these processes are not fully known. The recently delineated Hippo-tumor suppressor network and its two nuclear effectors, YAP and TAZ, shed light on these mechanisms. YAP and TAZ are proto-oncogene proteins that respond to complex physical milieu represented by the rigidity of the extracellular matrix, cell geometry, cell density, cell polarity and the status of the actin cytoskeleton. Here, we review the current knowledge of how YAP and TAZ function as mechanosensors and mechanotransducers. We also suggest that by deciphering the mechanical and biochemical signals controlling YAP/TAZ function, we will gain insights into new strategies for cancer treatment and organ regeneration.

KW - Hippo tumor suppressor

KW - Mechanosensor

KW - Mechanotransducer

KW - Organ size

KW - YAP/TAZ

UR - http://www.scopus.com/inward/record.url?scp=84905101429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905101429&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2014.04.012

DO - 10.1016/j.febslet.2014.04.012

M3 - Review article

VL - 588

SP - 2663

EP - 2670

JO - FEBS Letters

JF - FEBS Letters

SN - 0014-5793

IS - 16

ER -