Yellow fever vaccine - how does it work and why do rare cases of serious adverse events take place?

Alan Barrett, Dirk E. Teuwen

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Yellow fever 17D vaccine is one of the most successful vaccines ever developed and over 540 million doses have been used. Nevertheless there has been very little known about the mechanism of protection induced by the vaccine. The last couple of years have seen important advances made in understanding how the vaccine works involving studies of the innate and adaptive immune responses plus a systems biology approach. Like all vaccines, the 17D vaccine causes rare serious adverse events (SAEs) following immunization. At present, the mechanism(s) of SAEs is(are) poorly understood but our advances in understanding the immune response induced by the vaccine have promise to help elucidate the mechanism of SAEs.

Original languageEnglish (US)
Pages (from-to)308-313
Number of pages6
JournalCurrent Opinion in Immunology
Volume21
Issue number3
DOIs
StatePublished - Jun 2009

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Yellow Fever Vaccine
Vaccines
Systems Biology
Adaptive Immunity
Innate Immunity
Immunization

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Yellow fever vaccine - how does it work and why do rare cases of serious adverse events take place? / Barrett, Alan; Teuwen, Dirk E.

In: Current Opinion in Immunology, Vol. 21, No. 3, 06.2009, p. 308-313.

Research output: Contribution to journalArticle

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