@article{e736d5a20ba949c5a1b261828de98c9e,
title = "Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer{\textquoteright}s Disease",
abstract = "Alzheimer{\textquoteright}s disease (AD) is characterized by memory dysfunction, Aβ plaques together with phosphorylated tau-associated neurofibrillary tangles. Unfortunately, the present existing drugs for AD only offer mild symptomatic cure and have more side effects. As such, developments of effective, nontoxic drugs are immediately required for AD therapy. Present study demonstrates a novel role of Chinese medicine prescription Yuan-Hu Zhi Tong (YZT) in treating AD, and it has substantiated the in vivo effectiveness of YZT in two different transgenic mice models of AD, namely P301S tau and 3XTg-AD mice. Oral treatment of YZT significantly ameliorates motor dysfunction as well as promotes the clearance of aggregated tau in P301S tau mice. YZT improves the cognitive function and reduces the insoluble tau aggregates in 3XTg-AD mice model. Furthermore, YZT decreases the insoluble AT8 positive neuron load in both P301S tau and 3XTg-AD mice. Using microarray and the “Connectivity Map” analysis, we determined the YZT-induced changes in expression of signaling molecules and revealed the potential mechanism of action of YZT. YZT might regulate ubiquitin proteasomal system for the degradation of tau aggregates. The research results show that YZT is a potential drug candidate for the therapy of tau pathogenesis and memory decline in AD.",
keywords = "Alzheimer{\textquoteright}s disease, Chinese medicine, P301S tau mice, connectivity map, microarray, neurofibrillary tangles, yuan-hu zhi tong",
author = "A. Iyaswamy and Krishnamoorthi, {S. K.} and Liu, {Y. W.} and Song, {J. X.} and Kammala, {A. K.} and Sreenivasmurthy, {S. G.} and S. Malampati and Tong, {B. C.K.} and K. Selvarasu and Cheung, {K. H.} and Lu, {J. H.} and Tan, {J. Q.} and Huang, {C. Y.} and Durairajan, {S. S.K.} and M. Li",
note = "Funding Information: We would like to thank Prof. Michel Goedert (MRC Laboratory of Molecular Biology, Cambridge, UK) for his continuous support and supplying the P301S mice to allow us to establish a colony in our animal unit, Prof. Peter Davies (Albert Einstein College of Medicine, Bronx, NY, USA) for his continuous support and providing tau antibodies for the whole research work, Prof. Jian-dong Huang and Prof. Sookja K. Chung in HKU for providing the behavioral facility for the whole research work and Mr. Alan Ho for his technical assistance in the LCMS analysis of the herbal extracts and their pure compounds in HKBU. We would also like to thank Dr. Martha Dahlen for her English editing of this manuscript. Funding Information: This study was supported by the grants of Hong Kong Health and Medical Research Fund (HMRF 12132061, HMRF 14150811, HMRF 15163481, HMRF 17182541, HMRF 17182551), the General Research Fund from Hong Kong Government SAR (GRF/HKBU 12101417, GRF/HKBU 12100618), and research grant from the Hong Kong Baptist University (HKBU/RC-IRCs/ 17–18/03). This study also supported by the National Natural Science Foundation, China (NSFC 81773926, NSFC 81703487) Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Iyaswamy, Krishnamoorthi, Liu, Song, Kammala, Sreenivasmurthy, Malampati, Chun-Kit Tong, Selvarasu, CHEUNG, Lu, Tan, Huang, Durairajan and Min.",
year = "2020",
month = oct,
day = "30",
doi = "10.3389/fphar.2020.584770",
language = "English (US)",
volume = "11",
journal = "Frontiers in Pharmacology",
issn = "1663-9812",
publisher = "Frontiers Media S. A.",
}