Abstract
The effect of Z-100, a lipid-arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, was investigated on the resistance of thermally injured mice (TI-mice) to herpes simplex virus type 1 (HSV) infections. The susceptibility of TI mice to infection was about 100 times greater than it was in normal mice (N mice). However, the increased susceptibility of TI mice to infection was effectively counteracted to the levels observed in N mice when treated with Z-100 (10 mg/kg i.p.; 1, 3 and 5 days after thermal injury). Adoptive transfer of burn-associated CD8+ CD11b+ TCRγ/δ+ suppressor T (BAST) cells, prepared from TI mice, increased the susceptibility of N mice to infection by HSV, while the susceptibility of N mice, inoculated with the CD8+ T-cell fraction prepared from Z-100-treated TI mice (ZTC), to infection was not changed. In addition, the suppressor cell activity of BAST cells was not demonstrated when they were assayed in vitro in the presence of anti-IL-4 monoclonal antibody (mAb). BAST cells released IL-4 into their culture fluids without stimulation. The suppressor cell activity of ZTC and IL-4 production by ZTC were minimal. These results suggest that Z-100 may improve the resistance of TI mice to HSV infection through the regulation of BAST cells and/or the release of IL-4 from these cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 199-205 |
| Number of pages | 7 |
| Journal | Immunology Letters |
| Volume | 40 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 1 1994 |
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Keywords
- herpes virus
- Mycobacterium tuberculosis
- resistance
ASJC Scopus subject areas
- Immunology
- Immunology and Allergy
Cite this
Z-100, a lipid-arabinomannan extracted from Mycobacterium tuberculosis, improves the resistance of thermally injured mice to herpes virus infections. / Kobayashi, Makiko; Herndon, David; Pollard, Richard B.; Suzuki, Fujio.
In: Immunology Letters, Vol. 40, No. 3, 01.06.1994, p. 199-205.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Z-100, a lipid-arabinomannan extracted from Mycobacterium tuberculosis, improves the resistance of thermally injured mice to herpes virus infections
AU - Kobayashi, Makiko
AU - Herndon, David
AU - Pollard, Richard B.
AU - Suzuki, Fujio
PY - 1994/6/1
Y1 - 1994/6/1
N2 - The effect of Z-100, a lipid-arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, was investigated on the resistance of thermally injured mice (TI-mice) to herpes simplex virus type 1 (HSV) infections. The susceptibility of TI mice to infection was about 100 times greater than it was in normal mice (N mice). However, the increased susceptibility of TI mice to infection was effectively counteracted to the levels observed in N mice when treated with Z-100 (10 mg/kg i.p.; 1, 3 and 5 days after thermal injury). Adoptive transfer of burn-associated CD8+ CD11b+ TCRγ/δ+ suppressor T (BAST) cells, prepared from TI mice, increased the susceptibility of N mice to infection by HSV, while the susceptibility of N mice, inoculated with the CD8+ T-cell fraction prepared from Z-100-treated TI mice (ZTC), to infection was not changed. In addition, the suppressor cell activity of BAST cells was not demonstrated when they were assayed in vitro in the presence of anti-IL-4 monoclonal antibody (mAb). BAST cells released IL-4 into their culture fluids without stimulation. The suppressor cell activity of ZTC and IL-4 production by ZTC were minimal. These results suggest that Z-100 may improve the resistance of TI mice to HSV infection through the regulation of BAST cells and/or the release of IL-4 from these cells.
AB - The effect of Z-100, a lipid-arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, was investigated on the resistance of thermally injured mice (TI-mice) to herpes simplex virus type 1 (HSV) infections. The susceptibility of TI mice to infection was about 100 times greater than it was in normal mice (N mice). However, the increased susceptibility of TI mice to infection was effectively counteracted to the levels observed in N mice when treated with Z-100 (10 mg/kg i.p.; 1, 3 and 5 days after thermal injury). Adoptive transfer of burn-associated CD8+ CD11b+ TCRγ/δ+ suppressor T (BAST) cells, prepared from TI mice, increased the susceptibility of N mice to infection by HSV, while the susceptibility of N mice, inoculated with the CD8+ T-cell fraction prepared from Z-100-treated TI mice (ZTC), to infection was not changed. In addition, the suppressor cell activity of BAST cells was not demonstrated when they were assayed in vitro in the presence of anti-IL-4 monoclonal antibody (mAb). BAST cells released IL-4 into their culture fluids without stimulation. The suppressor cell activity of ZTC and IL-4 production by ZTC were minimal. These results suggest that Z-100 may improve the resistance of TI mice to HSV infection through the regulation of BAST cells and/or the release of IL-4 from these cells.
KW - herpes virus
KW - Mycobacterium tuberculosis
KW - resistance
UR - http://www.scopus.com/inward/record.url?scp=0028108623&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028108623&partnerID=8YFLogxK
U2 - 10.1016/0165-2478(93)00018-9
DO - 10.1016/0165-2478(93)00018-9
M3 - Article
C2 - 7959887
AN - SCOPUS:0028108623
VL - 40
SP - 199
EP - 205
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
IS - 3
ER -