Z-100, a lipid-arabinomannan extracted from Mycobacterium tuberculosis, improves the resistance of thermally injured mice to herpes virus infections

Makiko Kobayashi, David N. Herndon, Richard B. Pollard, Fujio Suzuki

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The effect of Z-100, a lipid-arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, was investigated on the resistance of thermally injured mice (TI-mice) to herpes simplex virus type 1 (HSV) infections. The susceptibility of TI mice to infection was about 100 times greater than it was in normal mice (N mice). However, the increased susceptibility of TI mice to infection was effectively counteracted to the levels observed in N mice when treated with Z-100 (10 mg/kg i.p.; 1, 3 and 5 days after thermal injury). Adoptive transfer of burn-associated CD8+ CD11b+ TCRγ/δ+ suppressor T (BAST) cells, prepared from TI mice, increased the susceptibility of N mice to infection by HSV, while the susceptibility of N mice, inoculated with the CD8+ T-cell fraction prepared from Z-100-treated TI mice (ZTC), to infection was not changed. In addition, the suppressor cell activity of BAST cells was not demonstrated when they were assayed in vitro in the presence of anti-IL-4 monoclonal antibody (mAb). BAST cells released IL-4 into their culture fluids without stimulation. The suppressor cell activity of ZTC and IL-4 production by ZTC were minimal. These results suggest that Z-100 may improve the resistance of TI mice to HSV infection through the regulation of BAST cells and/or the release of IL-4 from these cells.

Original languageEnglish (US)
Pages (from-to)199-205
Number of pages7
JournalImmunology Letters
Volume40
Issue number3
DOIs
StatePublished - Jun 1 1994

Keywords

  • Mycobacterium tuberculosis
  • herpes virus
  • resistance

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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