Zika Virus infection

A vector-borne threat to pregnant women and infants

Regina Grazel, Pamela Harris-Haman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Zika virus (ZIKV) is an emergent flavivirus, transmitted predominately by Aedes genus mosquitos that recently reached the Americas and was soon implicated in an increase in microcephaly and other serious birth defects. Purpose: This report provides updated information and recommendations on testing, screening, and care for pregnant women and infants affected by ZIKV. Methods: Current published recommendations from the Centers for Disease Control and Prevention, the World Health Organization, and the American Academy of Pediatrics were reviewed and included in this report. Results: Although largely a self-limiting disease usually without symptoms, pregnant women and their fetuses are at greatest risk. Maternal transmission of ZIKV to the fetus can lead to congenital Zika infection with potentially devastating sequelae to the infant. The available evidence suggests that infection during the first trimester of pregnancy, in which the fetus' central nervous system is being formed, is associated with higher risk of brain abnormalities and perinatal loss. Implications for Practice: Uncertainties remain about the course of the disease, and the full spectrum of effects of the virus on the developing infant is not yet understood. Infants with congenital Zika syndrome need coordinated follow-up and long-term specialty care, as well as support for the family. Implications for Research: There is no known cure for ZIKV infection and no vaccine is currently available. The full spectrum of developmental disabilities and other adverse early childhood outcomes associated with congenital ZIKV infection needs to be studied.

Original languageEnglish (US)
Pages (from-to)350-359
Number of pages10
JournalAdvances in Neonatal Care
Volume18
Issue number5
DOIs
StatePublished - Oct 1 2018
Externally publishedYes

Fingerprint

Pregnant Women
Fetus
Flavivirus
Microcephaly
Developmental Disabilities
Aedes
Long-Term Care
First Pregnancy Trimester
Centers for Disease Control and Prevention (U.S.)
Infection
Culicidae
Uncertainty
Vaccines
Central Nervous System
Mothers
Pediatrics
Viruses
Zika Virus Infection
Brain
Research

Keywords

  • congenital Zika infection
  • infants
  • pregnancy
  • Zika virus
  • ZIKV

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Zika Virus infection : A vector-borne threat to pregnant women and infants. / Grazel, Regina; Harris-Haman, Pamela.

In: Advances in Neonatal Care, Vol. 18, No. 5, 01.10.2018, p. 350-359.

Research output: Contribution to journalArticle

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