Zika Virus Infection and Solid Organ Transplantation: A New Challenge

M. L. Nogueira, C. F. Estofolete, A. C B Terzian, E. P B Mascarin do Vale, R. C M A da Silva, R. F. da Silva, H. J. Ramalho, I. M M Fernandes Charpiot, Nikos Vasilakis, M. Abbud-Filho

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Public health concerns exist surrounding the epidemic of the Zika virus (ZIKV) and the rapid growth of transplantation in developing countries, including endemic zones of active arbovirus transmission, as well as travel to such regions by potential organ donors and recipients. Few data exist regarding the clinical characteristics of ZIKV infection in immunocompromised hosts. Laboratory screening protocols for transplantation to differentiate ZIKV infections from other endemic viral diseases and for the detection of possible donor-derived infection have not been stated. The diagnosis of ZIKV infection remains a challenge, fueled by the lack of standardized commercially available diagnostic tests and validated reference diagnostic laboratories, as well as the limited duration of ZIKV viremia. In this small series, ZIKV infection in renal and liver recipients presented without rash, conjunctivitis, or neurological symptoms, and with abnormal graft function, thrombocytopenia, and bacterial superinfection. We report the first case series of ZIKV infection in solid organ recipients, with a description of clinical and laboratory features and therapeutic management.

Original languageEnglish (US)
Pages (from-to)791-795
Number of pages5
JournalAmerican Journal of Transplantation
Volume17
Issue number3
DOIs
StatePublished - Mar 1 2017

Keywords

  • clinical research/practice
  • infection and infectious agents
  • infection and infectious agents
  • infectious disease
  • viral

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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    Nogueira, M. L., Estofolete, C. F., Terzian, A. C. B., Mascarin do Vale, E. P. B., da Silva, R. C. M. A., da Silva, R. F., Ramalho, H. J., Fernandes Charpiot, I. M. M., Vasilakis, N., & Abbud-Filho, M. (2017). Zika Virus Infection and Solid Organ Transplantation: A New Challenge. American Journal of Transplantation, 17(3), 791-795. https://doi.org/10.1111/ajt.14047