Zika virus vaccines: Challenges and perspectives

Raquel Das Neves Almeida, Trina Racine, Kelly G. Magalhães, Gary P. Kobinger

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These significant clinical manifestations have led investigators to develop several candidate vaccines specific to Zika virus. In this review we describe relevant targets for the development of vaccines specific for Zika virus, the development status of various vaccine candidates and their different platforms, as well as their clinical progression.

Original languageEnglish (US)
Article number62
JournalVaccines
Volume6
Issue number3
DOIs
StatePublished - Sep 13 2018
Externally publishedYes

Keywords

  • Animal models
  • Challenge
  • Clinical trials
  • Flaviviruses
  • Immune responses
  • Immunopathology
  • Vaccines
  • Zika virus

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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